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Titolo:
Effect of estrogen on flow-induced dilation in NO deficiency: role of prostaglandins and EDHF
Autore:
Huang, A; Wu, YM; Sun, D; Koller, A; Kaley, G;
Indirizzi:
New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA New York Med CollValhalla NY USA 10595 t Physiol, Valhalla, NY 10595 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 91, anno: 2001,
pagine: 2561 - 2566
SICI:
8750-7587(200112)91:6<2561:EOEOFD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEMALE HYPERTENSIVE RATS; NITRIC-OXIDE; HYPERPOLARIZING FACTOR; SHEAR-STRESS; RELATIVE CONTRIBUTIONS; ENDOTHELIAL-CELLS; ARTERIOLES; EXPRESSION; 17-BETA-ESTRADIOL; CYCLOOXYGENASE-2;
Keywords:
ovariectomy; estrogen replacement; potassium channels; arterioles; endothelium-derived hyperpolarizing factor; nitric oxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Huang, A New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA New York Med Coll Valhalla NY USA 10595 , Valhalla, NY 10595 USA
Citazione:
A. Huang et al., "Effect of estrogen on flow-induced dilation in NO deficiency: role of prostaglandins and EDHF", J APP PHYSL, 91(6), 2001, pp. 2561-2566

Abstract

To investigate the role of estrogen in flow-induced dilation (FiD) in nitric oxide (NO) deficiency, FiD was examined in isolated gracilis arterioles of ovariectomized (OVX) and OVX rats with estrogen replacement (OVE). Both groups of rats were treated chronically with N-omega-nitro-L-arginine methyl ester. Plasma concentration of NO2/NO3 was reduced in both groups. Plasmaconcentration of estradiol was lower in OVX than in OVE rats. FiD was similar in vessels of the two groups; calculated wall shear stress and basal tone were significantly greater in OVX vs. OVE rats. Indomethacin did not affect FiD in vessels from OVE, rats but abolished dilation in vessels from OVX rats. Valeryl salicylate or NS-398 inhibited FiD by similar to 50%, whereas their simultaneous administration eliminated the response in arterioles from OVX rats. In vessels from OVE rats, miconazole or charybdotoxin eliminated FiD. Thus, in NO deficiency, prostaglandins derived from both cyclooxygenase isoforms mediate FiD in gracilis arterioles of OVX rats. Estrogen replacement switches the mediation, showing dependence on endothelium-derivedhyperpolarizing factor in the arterioles of OVE rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 07:57:20