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Titolo:
Inhibitory effects of voluntary wheel exercise on apoptosis in splenic lymphocyte subsets of C57BL/6 mice
Autore:
Avula, CPR; Muthukumar, AR; Zaman, K; McCarter, R; Fernandes, G;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Med, Div Clin Immunol, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 in Immunol, San Antonio, TX 78229 USA Univ Texas, Hlth Sci Ctr, Dept Physiol, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 pt Physiol, San Antonio, TX 78229 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 6, volume: 91, anno: 2001,
pagine: 2546 - 2552
SICI:
8750-7587(200112)91:6<2546:IEOVWE>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE-SYSTEM; TREADMILL EXERCISE; OXIDATIVE STRESS; TRAINED RATS; VITAMIN-E; SUPEROXIDE-DISMUTASE; ANTIOXIDANT ENZYMES; LIPID-PEROXIDATION; FLOW-CYTOMETRY; CELL-DEATH;
Keywords:
H2O2; dexamethasone; tumor necrosis factor-alpha; anti-CD3; antioxidant enzymes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Fernandes, G Univ Texas, Hlth Sci Ctr, Dept Med, Div Clin Immunol, Mail Code 7874,7703 Floyd Curl Dr, San Antonio, TX 78229 USA Univ Texas Mail Code 7874,7703 Floyd Curl Dr San Antonio TX USA 78229
Citazione:
C.P.R. Avula et al., "Inhibitory effects of voluntary wheel exercise on apoptosis in splenic lymphocyte subsets of C57BL/6 mice", J APP PHYSL, 91(6), 2001, pp. 2546-2552

Abstract

Two-month-old mice were placed in cages with (Ex) or without exercise running wheels with free access to the wheel 24 h/day for 10 mo. An equal amount of food for both groups was provided daily. Ex mice ran an average of 33.67 km/wk initially, and exercise decreased gradually with age. Ex mice had gained an average of 43.5% less body weight at the end of the experiment. Although serum lipid peroxides were not altered by exercise, superoxide dismutase and glutathione peroxidase activities in serum were significantly increased. Flow cytometric analysis of spleen cells revealed an increased percentage of CD8(+) T cells and a decreased percentage of CD19(+) B cells in Ex mice (P < 0.05). Exercise decreased apoptosis in total splenocytes and CD4(+) cells incubated with medium alone or with H2O2, dexamethasone, tumor necrosis factor-<alpha> (TNF-alpha), or anti-CD3 monoclonal antibody (P < 0.05) and CD8(+) cells with medium alone or with TNF-<alpha> (P < 0.05). Eventhough exercise did not alter the intracellular cytokines (TNF-<alpha> andinterleukin-2) or Fas ligand, it did significantly lower interferon-gamma in CD4(+) and CD8(+) cells (P < 0.05). In summary, voluntary wheel exerciseappears to decrease H2O2-induced apoptosis in immune cells as well as decrease interferon-<gamma> production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:10:00