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Titolo:
Liquid chromatography/electrospray ionization/isotopic dilution mass spectrometry analysis of n-(phosphonomethyl) glycine and mass spectrometry analysis of aminomethyl phosphonic acid in environmental water and vegetation matrixes
Autore:
Grey, L; Nguyen, B; Yang, P;
Indirizzi:
Ontario Minist Environm, Appl Chromatog Sect, Etobicoke, ON M9P 3V6, Canada Ontario Minist Environm Etobicoke ON Canada M9P 3V6 e, ON M9P 3V6, Canada
Titolo Testata:
JOURNAL OF AOAC INTERNATIONAL
fascicolo: 6, volume: 84, anno: 2001,
pagine: 1770 - 1780
SICI:
1060-3271(200111/12)84:6<1770:LCIDMS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
(AMINOMETHYL)PHOSPHONIC ACID; 9-FLUORENYLMETHYL CHLOROFORMATE; FLUORESCENCE DETECTION; PRECOLUMN DERIVATIZATION; GAS-CHROMATOGRAPHY; NATURAL-WATERS; GLYPHOSATE; METABOLITE; RESIDUES; HERBICIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, P Ontario Minist Environm, Appl Chromatog Sect, 125 Resources Rd, Etobicoke,ON M9P 3V6, Canada Ontario Minist Environm 125 Resources Rd Etobicoke ON Canada M9P 3V6
Citazione:
L. Grey et al., "Liquid chromatography/electrospray ionization/isotopic dilution mass spectrometry analysis of n-(phosphonomethyl) glycine and mass spectrometry analysis of aminomethyl phosphonic acid in environmental water and vegetation matrixes", J AOAC INT, 84(6), 2001, pp. 1770-1780

Abstract

A liquid chromatography/electrospray/mass spectrometry (LC/ES/MS) method was developed for the analysis of glyphosate (n-phosphonomethyl glycine) andits metabolite, aminomethyl phosphonic acid (AMPA) using isotope-labelled glyphosate as a method surrogate. Optimized parameters were achieved to derivatize glyphosate and AMPA using 9-fluorenylmethyl chloroformate (FMOC-Cl)in borate buffer prior to a reversed-phase LC analysis. Method spike recovery data obtained using laboratory and real world sample matrixes indicatedan excellent correlation between the recovery of the native and isotope-labelled glyphosate. Hence, the first performance-based, isotope dilution MS method with superior precision, accuracy, and data quality was developed for the analysis of glyphosate. There was, however, no observable correlationbetween the isotope-labelled glyphosate and AMPA. Thus, the use of this procedure for the accurate analysis of AMPA was not supported. Method detection limits established using standard U.S. Environmental Protection Agency protocol were 0.06 and 0.30 mug/L, respectively, for glyphosate and AMPA in water matrixes and 0.11 and 0.53 mug/g, respectively, in vegetation matrixes. Problems, solutions, and the method performance data related to the analysis of chlorine-treated drinking water samples are discussed. Applying this method to other environmental matrixes, e.g., soil, with minimum modifications is possible, assuring accurate, multimedia studies of glyphosate concentration in the environment and the delivery of useful multimedia information for regulatory applications.

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Documento generato il 04/06/20 alle ore 01:47:49