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Titolo:
Selective liquid chromatographic method for determination of fluoxetine inplasma
Autore:
Zarghi, A; Kebriaeezadeh, A; Ahmadkhaniha, R; Akhgari, M; Rastkari, N;
Indirizzi:
Shaheed Beheshti Univ Med Sci, Dept Pharm, Tehran, Iran Shaheed Beheshti Univ Med Sci Tehran Iran Sci, Dept Pharm, Tehran, Iran Tehran Univ Med Sci, Dept Toxicol & Pharmacol, Fac Pharm, Tehran, Iran Tehran Univ Med Sci Tehran Iran ol & Pharmacol, Fac Pharm, Tehran, Iran
Titolo Testata:
JOURNAL OF AOAC INTERNATIONAL
fascicolo: 6, volume: 84, anno: 2001,
pagine: 1735 - 1737
SICI:
1060-3271(200111/12)84:6<1735:SLCMFD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-CAPTURE DETECTION; FLUORESCENCE DETECTION; GAS-CHROMATOGRAPHY; METABOLITE NORFLUOXETINE; ANTIDEPRESSANT RESPONSE; ULTRAVIOLET DETECTION; SERUM; HPLC; AMITRIPTYLINE; ENANTIOMERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Zarghi, A Shaheed Beheshti Univ Med Sci, Dept Pharm, Tehran, Iran Shaheed Beheshti Univ Med Sci Tehran Iran Pharm, Tehran, Iran
Citazione:
A. Zarghi et al., "Selective liquid chromatographic method for determination of fluoxetine inplasma", J AOAC INT, 84(6), 2001, pp. 1735-1737

Abstract

A selective and sensitive liquid chromatographic method was developed for the determination of fluoxetine (FLU) in plasma. FLU was isolated from plasma by liquid-liquid extraction. The chromatographic separation was performed on an analytical 250 x 3.9 mm id Novapak C-18 column (4 mum particle size) with an isocratic mobile phase consisting of phosphate buffer-acetonitrile-methanol-triethylamine (58 + 30 + 10 + 2, v/v) adjusted to pH 7. Using UVdetection at 226 nm, the detection limit for FLU in plasma was 3 ng/mL. Nointerferences were found with tricyclic antidepressant drugs, which allowsthis method to be used in clinical studies. The calibration curve was linear over the concentration range of 10-200 ng/mL. The average recovery was about 80% for plasma. The inter- and intraday assay coefficients of variation were <8%.

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Documento generato il 19/01/20 alle ore 11:33:39