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Titolo:
Progress in the development of caloric restriction mimetic dietary supplements
Autore:
Mattson, MP; Duan, WZ; Lee, J; Guo, ZH; Roth, GS; Ingram, DK; Lane, MA;
Indirizzi:
NIA, Neurosci Lab, Ctr Gerontol Res, Baltimore, MD 21224 USA NIA Baltimore MD USA 21224 Lab, Ctr Gerontol Res, Baltimore, MD 21224 USA Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 urosci, Baltimore, MD 21205 USA
Titolo Testata:
JOURNAL OF ANTI-AGING MEDICINE
fascicolo: 3, volume: 4, anno: 2001,
pagine: 225 - 232
SICI:
1094-5458(200123)4:3<225:PITDOC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTECTS HIPPOCAMPAL-NEURONS; CORTICAL SYNAPTIC TERMINALS; AMYLOID BETA-PEPTIDE; SACCHAROMYCES-CEREVISIAE; MITOCHONDRIAL-FUNCTION; GLUTAMATE TRANSPORT; PARKINSONS-DISEASE; BRAIN-DAMAGE; LIFE-SPAN; 2-DEOXY-D-GLUCOSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Mattson, MP NIA, Neurosci Lab, Ctr Gerontol Res, Baltimore, MD 21224 USA NIA Baltimore MD USA 21224 ontol Res, Baltimore, MD 21224 USA
Citazione:
M.P. Mattson et al., "Progress in the development of caloric restriction mimetic dietary supplements", J ANTI-AG M, 4(3), 2001, pp. 225-232

Abstract

Caloric restriction (CR)-or reduced calorie intake with nutritional maintenance-can extend lifespan and increase resistance to age-related disease bymechanisms which likely involve reduced oxyradical production and cellularhormesis responses in which genes encoding cytoprotective proteins are upregulated. Recent studies suggest that several of the anti-aging effects of CR can be mimicked by giving animals compounds that reduce energy availability at the cellular level. Such CR mimetic compounds (e.g., 2-deoxy-D-glucose, phenformin and iodoacetate) have proven beneficial in experimental models of neurodegenerative disorders and cancer. CR mimetics appear to act viaa hormesis-based mechanism in which cells upregulate heat-shock and other chaperone proteins, and growth factors. Although long-term effects of dietary supplementation with such CR mimetics remain to be determined, the initial findings reviewed here suggest a novel approach for the investigation ofbasic mechanisms of aging, for the possible extension of lifespan without CR, and for dealing with the rising tide of obesity in industrialized countries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:32:12