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Titolo:
Endocrine effects of dietary restriction and aging: The National Instituteon Aging Study
Autore:
Mattison, JA; Roth, GS; Ingram, DK; Lane, MA;
Indirizzi:
Neurosci Lab, Baltimore, MD USA Neurosci Lab Baltimore MD USANeurosci Lab, Baltimore, MD USA
Titolo Testata:
JOURNAL OF ANTI-AGING MEDICINE
fascicolo: 3, volume: 4, anno: 2001,
pagine: 215 - 223
SICI:
1094-5458(200123)4:3<215:EEODRA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN GROWTH-HORMONE; DEHYDROEPIANDROSTERONE-SULFATE; CARDIOVASCULAR-DISEASE; CALORIE RESTRICTION; DIABETES-MELLITUS; NONHUMAN-PRIMATES; RHESUS-MONKEYS; PINEAL-GLAND; SERUM; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Mattison, JA Neurosci Lab, Baltimore, MD USA Neurosci Lab Baltimore MD USA urosci Lab, Baltimore, MD USA
Citazione:
J.A. Mattison et al., "Endocrine effects of dietary restriction and aging: The National Instituteon Aging Study", J ANTI-AG M, 4(3), 2001, pp. 215-223

Abstract

Calorie restriction (CR) has been shown repeatedly to extend lifespan and reduce the incidence of age-related disease in a variety of animal models. Rhesus monkeys experience many age-related changes in hormone function thatparallel those observed in humans and evidence suggests that CR is a safe and effective means for slowing many of these aging changes. In the National Institute on Aging (NIA) long-term study on rhesus monkeys, CR improved glucoregulatory function and disrupted both the thyroid and growth hormone axis, all of which may be important for mediating the effects of CR. Male monkeys experienced delayed puberty. However, data from old females indicatedthat restriction did not alter hormone levels or cycling-thus, reducing the potential risk of reproductive dysfunction due to lower caloric intake. While it is certainly advantageous to document improved health and longevity, the long lifespan of nonhuman primates dictates the need to develop physiological biomarkers of aging. Dehydroepiandrosterone (DHEA) and melatonin have met criteria as such and CR was shown to attenuate the age-related decline of these hormones in monkeys. This review summarizes selected findings on the hormonal changes elicited by CR in aging rhesus monkeys.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:31:49