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Titolo:
Synthesis and quantitative structure-activity relationships of fluorine-containing 4,4-dihydroxylmethyl-2-aryliminooxazo(thiazo)lidines as trehalase inhibitors
Autore:
Qian, XH; Liu, Z; Li, ZB; Li, Z; Song, GH;
Indirizzi:
Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China Dalian Univ Technol Dalian Peoples R China 116012 16012, Peoples R China E China Univ Sci & Technol, Inst Pesticides & Pharmaceut, Shanghai 200237,Peoples R China E China Univ Sci & Technol Shanghai Peoples R China 200237 oples R China
Titolo Testata:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
fascicolo: 11, volume: 49, anno: 2001,
pagine: 5279 - 5284
SICI:
0021-8561(200111)49:11<5279:SAQSRO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TREHAZOLIN ANALOGS; CASTANOSPERMINE; MOIETIES;
Keywords:
fluorine-containing,4,4-dihydroxylmethyl-2-anilino-oxazo(thiazo)lidines; trehalase inhibitors; insect flight; synthesis; QSAR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Qian, XH Dalian Univ Technol, State Key Lab Fine Chem, POB 40,158 Zhongshan Rd, Dalian 116012, Peoples R China Dalian Univ Technol POB 40,158 Zhongshan Rd Dalian Peoples R China 116012
Citazione:
X.H. Qian et al., "Synthesis and quantitative structure-activity relationships of fluorine-containing 4,4-dihydroxylmethyl-2-aryliminooxazo(thiazo)lidines as trehalase inhibitors", J AGR FOOD, 49(11), 2001, pp. 5279-5284

Abstract

Five fluorine-containing 4,4-dihydroxylmethyl-2-aryliminooxazolidines and five 4,4-dihydroxylmethyl-2-aryliminothiazolidines were synthesized and evaluated for their inhibitory activity against trehalase in vitro. All these compounds were very readily synthesized compared with the natural trehalaseinhibitors. They had moderate inhibitory activity toward trehalase, and showed larvicidal activity and inhibition action to insect flight. The stericparameters and semiempirical quantum parameters of these compounds were acquired by using the molecular modeling method and the PM3-SCF-MO method, respectively. A quantitative structure-activity relationship between half-inhibitory concentrations toward trehalase and the above parameters was established.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:51:41