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Titolo:
Relationship between cardiac I-123-metaiodobenzylguanidine imaging and thetranscardiac gradient of neurohumoral factors in patients with dilated cardiomyopathy
Autore:
Matsui, T; Tsutamoto, T; Kinoshita, M;
Indirizzi:
Shiga Univ Med Sci, Dept Internal Med 1, Otsu, Shiga 5202152, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202152 1, Otsu, Shiga 5202152, Japan
Titolo Testata:
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
fascicolo: 12, volume: 65, anno: 2001,
pagine: 1041 - 1046
SICI:
0047-1828(200112)65:12<1041:RBCIIA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; BRAIN NATRIURETIC PEPTIDE; LEFT-VENTRICULAR DYSFUNCTION; FAILING HUMAN HEART; PLASMA NOREPINEPHRINE; BIOCHEMICAL MARKER; NERVOUS ACTIVITY; PROGNOSTIC VALUE; BLOCKER THERAPY; BETA-BLOCKER;
Keywords:
dilated cardiomyopathy; metaiodobenzylguanidine (MIBG); neurohumoral factors; transcardiac gradient;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Tsutamoto, T Shiga Univ Med Sci, Dept Internal Med 1, Otsu, Shiga 5202152,Japan Shiga Univ Med Sci Otsu Shiga Japan 5202152 a 5202152, Japan
Citazione:
T. Matsui et al., "Relationship between cardiac I-123-metaiodobenzylguanidine imaging and thetranscardiac gradient of neurohumoral factors in patients with dilated cardiomyopathy", JPN CIRC J, 65(12), 2001, pp. 1041-1046

Abstract

Cardiac sympathetic nervous function is altered in congestive heart failure (CHF) and the uptake and washout rate of cardiac I-123-metaiodobenzylguanidine (MIBG) are useful markers for evaluating the severity of it. To assess what parameters predict decreased uptake or increased washout rate of MIBG, the concentrations of neurohumoral factor in both the aorta (Ao) and coronary sinus (CS) were measured, as well as hemodynamic parameters by catheterization, in patients with dilated cardiomyopathy (DCM). MIBG imaging was performed within 1 week of cardiac catheterization. Regarding MIBG parameters, the correlation with the transcardiac gradient of norepinephrine (NE), brain natriuretic peptide (BNP) and hemodynamics was investigated. Stepwisemultivariate regression analysis was used to determine which variables closely correlated with cardiac MIBG parameters. There was a significant increase in the NE level between the Ao (446pg/ml) and the CS (727pg/ml). According to stepwise multivariate regression analysis, the heart/mediastinum (H/M) ratio independently correlated with the transcardiac gradient of BNP (r=-0.480, p <0.01), and the washout rate independently correlated with the transcardiac gradient of NE (r=0.48 1, p <0.01). These findings indicate thatthe H/M ratio may reflect the transcardiac gradient of BNP, which implies the degree of left ventricular dysfunction and/or damage and the washout rate may reflect altered cardiac sympathetic nerve terminal in DCM patients with CHF, suggesting that both the H/M ratio and washout rate provide important information about the failing ventricle.

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Documento generato il 30/03/20 alle ore 13:27:45