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Titolo:
Artificial oxygen carriers - The new doping threat in endurance sport?
Autore:
Schumacher, YO; Schmid, A; Dinkelmann, S; Berg, A; Northoff, H;
Indirizzi:
Univ Freiburg, Med Klin, Abt Rehabil Pravent & Sportmed, D-79106 Freiburg,Germany Univ Freiburg Freiburg Germany D-79106 portmed, D-79106 Freiburg,Germany Univ Tubingen, Abt Transfus Med, Tubingen, Germany Univ Tubingen Tubingen Germany gen, Abt Transfus Med, Tubingen, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
fascicolo: 8, volume: 22, anno: 2001,
pagine: 566 - 571
SICI:
0172-4622(200111)22:8<566:AOC-TN>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED HEMOGLOBIN DCLHB(TM); HUMAN-ERYTHROPOIETIN ABUSE; BLOOD SUBSTITUTES; BOVINE HEMOGLOBIN; CELL SUBSTITUTES; PHASE-I; PERFORMANCE; TRANSFUSION; ELIMINATION; EXERCISE;
Keywords:
blood substitutes; performance; hemoglobin; perfluorocarbon; sport; doping;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Schumacher, YO Univ Freiburg, Med Klin, Abt Rehabil Pravent & Sportmed, Hugstetter Str 55, D-79106 Freiburg, Germany Univ Freiburg Hugstetter Str 55 Freiburg Germany D-79106 y
Citazione:
Y.O. Schumacher et al., "Artificial oxygen carriers - The new doping threat in endurance sport?", INT J SP M, 22(8), 2001, pp. 566-571

Abstract

Maximal oxygen uptake is the major performance limiting factor in endurance sports. Sophisticated training methods have been developed to increase this variable. On the other hand, attempts have been made to improve maximal oxygen uptake by artificial means: blood doping and the misuse of recombinant human erythropoietin have beneficial effects on aerobic exercise capacity. Both methods have been banned by international sporting federations. A new class of substances might represent the next step of fraudulent improvement of the maximal oxygen uptake: artificial oxygen carriers, such as solutions based on recombinant, bovine or human hemoglobin and perfluorocarbon-emulsions have been shown to improve oxygen delivery to the muscle. Hemoglobin-based solutions improve aerobic exercise capacity in animal and human testing. Both substances have potentially lethal side effects including renaltoxicity, increased systemic and pulmonary blood pressure and impairment of the immune system. Hemoglobin-based carriers can be detected in drug testing with routine laboratory tests based on the detection of free hemoglobin. Perfluorocarbon is not metabolized by the body and exhaled through the lung and can be measured with chromatography. No screening for these substances in drug tests has been performed so far. International sporting federations should be aware of this new, emerging doping threat.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:45:48