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Titolo:
Enhanced glucose uptake into adipose tissue induced by early growth restriction augments excursions in plasma leptin response evoked by changes in insulin status
Autore:
Holness, MJ;
Indirizzi:
Univ London, Dept Diabet & Metab Med, Div Gen & Dev Med, St Bartholomews &Royal London Sch Med & Dent, London E1 4NS, England Univ London London England E1 4NS Sch Med & Dent, London E1 4NS, England
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 12, volume: 25, anno: 2001,
pagine: 1775 - 1781
SICI:
0307-0565(200112)25:12<1775:EGUIAT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBOPTIMAL PROTEIN NUTRITION; OBESE GENE; SKELETAL-MUSCLE; RAT ADIPOCYTES; SECRETION; MICE; RESISTANCE; METABOLISM; EXPRESSION; WEIGHT;
Keywords:
leptin; insulin; adipose tissue; glucose uptake; early-life programming;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Holness, MJ Univ London, Dept Diabet & Metab Med, Div Gen & Dev Med, St Bartholomews &Royal London Sch Med & Dent, Med Sci Bldg,Mile End Rd, London E1 4NS, England Univ London Med Sci Bldg,Mile End Rd London England E1 4NS nd
Citazione:
M.J. Holness, "Enhanced glucose uptake into adipose tissue induced by early growth restriction augments excursions in plasma leptin response evoked by changes in insulin status", INT J OBES, 25(12), 2001, pp. 1775-1781

Abstract

Objective: The study used a rat model of moderate protein restriction exclusively during fetal and early neonatal life, which has been established tocause intrauterine early growth retardation, to investigate possible association between adipocyte glucose utilisation and leptin secretion in vivo. Design: These rats, termed early protein restricted, were transferred to adiet containing the standard amount of protein at weaning and remained on this diet until adulthood, at which time adipocyte glucose utilisation and leptin secretion was compared with that of age-matched controls. Insulin status was modulated by acute (2 h) insulin infusion at a constant rate (4.2 mU/min per kg) to elevate insulin to the high physiological range. Euglycaemia was maintained by variable glucose infusion. Measurements: Glucose utilisation was measured in vivo in conscious unrestrained rats using 2-deoxy[1-H-3] glucose. Leptin concentrations (measured by radioimmunoassay) and whole-body glucose kinetics (measured using [3-H-3]glucose) were studied in the postabsorptive state and after acute insulin stimulation. Results: Adipose-tissue glucose utilisation rates in vivo tended to be higher in the post-absorptive state and were consistently 1.8-3.0-fold higher after insulin stimulation in the early-protein-restricted group compared with the control group. Both the absolute increase in leptin concentration elicited by hyperinsulinaemia and the magnitude of the effect of insulin to elevate plasma leptin levels were greater in the early-protein-restricted group compared with the control group (by 2.2-fold and 1.6-fold, respectively). The effect of insulin to stimulate R-d was much greater in the early-protein-restricted group (4.1-fold) than in the control group (2.2-fold) and the absolute increase in R-d elicited by insulin was 43% higher in the early-protein-restricted group than in the control group. Conclusions: It is concluded that poor early growth enhances the acute leptin response to changes in insulin status through programmed changes in adipocyte glucose handling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:25:08