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Titolo:
Biological monitoring of exposure of the general population to the organophosphorus pesticides chlorpyrifos and chlorpyrifos-methyl by determination of their specific metabolite 3,5,6-trichloro-2-pyridinol
Autore:
Koch, HM; Hardt, J; Angerer, J;
Indirizzi:
Univ Erlangen Nurnberg, Inst Outpatient Clin Occupat Social & Environm Me,D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054-91054 Erlangen, Germany Augsburg Hosp, Inst Lab Med Microbiol & Environm Hyg, D-86156 Augsburg, Germany Augsburg Hosp Augsburg Germany D-86156 nm Hyg, D-86156 Augsburg, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
fascicolo: 2-3, volume: 204, anno: 2001,
pagine: 175 - 180
SICI:
1438-4639(200111)204:2-3<175:BMOEOT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MASS-SPECTROMETRY; URINE;
Keywords:
biological monitoring; general population; pesticides; urine; chlorpyrifos; chlorpyrifos-methyl; 3,5,6-trichloro-2-pyridinol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Angerer, J Univ Erlangen Nurnberg, Inst Outpatient Clin Occupat Social & Environm Me,Schillerstr 25-29, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Schillerstr 25-29 Erlangen Germany D-91054
Citazione:
H.M. Koch et al., "Biological monitoring of exposure of the general population to the organophosphorus pesticides chlorpyrifos and chlorpyrifos-methyl by determination of their specific metabolite 3,5,6-trichloro-2-pyridinol", INT J HYG E, 204(2-3), 2001, pp. 175-180

Abstract

In this study we determined the concentrations of 3,5,6-trichloro-2-pyridinol (TCPyr) in urine samples from the general population. TCPyr is a specific metabolite of the organophosphorus pesticides chlorpyrifos and chlorpyrifos-methyl. By the introduction of a new sensitive analytical method a limit Of quantification (LOQ) of 0.1 mug per litre urine could be achieved, a tenfold improvement of recent methods. Extraction of TCPyr from the urine and the clean up process were carried out by automatic steam distillation. Separation and quantitative analysis were performed using capillary gas chromatography and mass selective detection in selected ion monitoring mode. The excretion of TCPyr was studied by analysing spontaneous urine samples from 5 women and 45 men between the ages of 22 and 57 (median: 40 years) living in Mecklenburg-Vorpommern (Germany) who were not occupationally exposed to organophosporus pesticides. TCPyr was detected in all specimens and the concentrations were quantified. The median excretion was 1.4 mug/l,(range: 0.12 to 124.8 mug/l), the 95th percentile 11.3 mug/l. Under the worst case assumption that all TCPyr measured in urine originated from the intake ofintact pesticides and not (less toxic) breakdown products, a TCPyr concentration of 1.4 mug/l urine corresponds to a daily intake of approximately 2.5 mug chlorpyrifos/ chlorpyrifos-methyl. The intake at the 95th percentile would be about 23 R chlorpyrifos/ chlorpyrifos-methyl per day. According toFAO/WHO the acceptable daily intake (ADI) is 10 mug per kg bodyweight and day for both chlorpyrifos and chlorpyrifos-methyl.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:19:36