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Titolo:
The relationship between expression of p53/Bcl-2 and histopathological criteria in breast invasive ductal carcinomas
Autore:
Gursan, N; Karakok, M; Sari, I; Gursan, MS;
Indirizzi:
Ataturk Univ, Sch Med, Dept Pathol, Erzurum, Turkey Ataturk Univ ErzurumTurkey Univ, Sch Med, Dept Pathol, Erzurum, Turkey Ataturk Univ, Sch Med, Dept Surg, Erzurum, Turkey Ataturk Univ Erzurum Turkey k Univ, Sch Med, Dept Surg, Erzurum, Turkey Gaziantep Univ, Sch Med, Dept Pathol, Gaziantep, Turkey Gaziantep Univ Gaziantep Turkey Sch Med, Dept Pathol, Gaziantep, Turkey
Titolo Testata:
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
fascicolo: 9, volume: 55, anno: 2001,
pagine: 589 - 590
SICI:
1368-5031(200111)55:9<589:TRBEOP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BCL-2 IMMUNOREACTIVITY; P53; CANCER; APOPTOSIS; PROGNOSIS; LESIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Karakok, M Inonu Cad 35, TR-27100 Gaziantep, Turkey Inonu Cad 35 Gaziantep Turkey TR-27100 7100 Gaziantep, Turkey
Citazione:
N. Gursan et al., "The relationship between expression of p53/Bcl-2 and histopathological criteria in breast invasive ductal carcinomas", INT J CL PR, 55(9), 2001, pp. 589-590

Abstract

Seventy-five cases of invasive ductal carcinoma (IDC) on whom axillary lymph node dissection and mastectomy were performed between 1996 and 2000 werereviewed histopathologically. The slides were stained immunohistologicallywith p53 and Bcl-2. In 40 cases we observed 53% Bcl-2 and 69% p53 positivity There were correlations between p53 and tumour grade, and also between p53 and Bcl-2. We did not observe any connection between the main histopathological prognostic factors - lymph node metastasis, tumour size, tubule formation, pleomorphism - and p53/Bcl-2. In our study, IDC with a high mitoticindex and poor differentiation showed mutant p53 positive staining. Expression of Bcl-2 is associated with low nuclear grade and absence of mutant p53. This study was designed to reveal the correlation between histopathological findings and the expression of p53/Bcl-2 on prognosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 21:49:01