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Titolo:
Effects of the quantity of water and milk ingested concomitantly with AS-924, a novel ester-type cephem antibiotic, on its pharmacokinetics
Autore:
Matsumoto, F; Sakurai, I; Morita, M; Takahashi, T; Mori, N; Sugihara, T; Sakai, A; Yamaji, S; Akaike, Y; Yano, K;
Indirizzi:
Asahi Kasei Corp, Pharmacokinet Res Inst, Chiyoda Ku, Tokyo 1018481, JapanAsahi Kasei Corp Tokyo Japan 1018481 t, Chiyoda Ku, Tokyo 1018481, Japan Kanagawa Prefecture Midwives & Nurses Training Sc, Isogo Ku, Yokohama, Kanagawa 2350022, Japan Kanagawa Prefecture Midwives & Nurses Training Sc Yokohama Kanagawa Japan 2350022 Asahi Kasei Corp, Clin Dev Ctr, Chiyoda Ku, Tokyo 1018481, Japan Asahi Kasei Corp Tokyo Japan 1018481 r, Chiyoda Ku, Tokyo 1018481, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
fascicolo: 5, volume: 18, anno: 2001,
pagine: 471 - 476
SICI:
0924-8579(200111)18:5<471:EOTQOW>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ABSORPTION;
Keywords:
AS-924 ceftizoxime; prodrug; water; milk; absorbtion; antibiotic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Yamaji, S Asahi Kasei Corp, Pharmacokinet Res Inst, Chiyoda Ku, 9-1 Kanda Mitoshirocho, Tokyo 1018481, Japan Asahi Kasei Corp 9-1 Kanda Mitoshirocho Tokyo Japan 1018481 pan
Citazione:
F. Matsumoto et al., "Effects of the quantity of water and milk ingested concomitantly with AS-924, a novel ester-type cephem antibiotic, on its pharmacokinetics", INT J ANT A, 18(5), 2001, pp. 471-476

Abstract

The effect of the quantity of water ingested concomitantly with drugs, on the absorption of AS-924, a novel prodrug-type cephem antibiotic, was studied in five healthy adult volunteers by a cross-over method, using cefteram-pivoxil (CTER-PI) as the control drug. In addition, the effect of milk on the absorption of AS-924 was also investigated. The absorption of CTER-PI was significantly reduced when administered together with 30 ml of water compared with its absorption when administered together with 150 ml of water, whereas no such reduction was found in the case of AS-924. Ingestion of milkdid not significantly affect the absorption of AS-924. These results confirm that absorption of AS-924 after oral administration is not likely to be affected by the quantity of water taken concomitantly with the drug, nor bymilk. (C) 2001 Published by Elsevier Science B.V. and International Society of Chemotherapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:50:49