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Titolo:
Molecular surveillance of macrolide, tetracycline and quinolone resistancemechanisms in 1191 clinical European Streptococcus pneumoniae isolates
Autore:
Schmitz, FJ; Perdikouli, M; Beeck, A; Verhoef, J; Fluit, AC;
Indirizzi:
Univ Utrecht, Med Ctr, Eijkman Winkler Inst, NL-3508 GA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands Univ Dusseldorf, Inst Med Microbiol & Virol, Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany crobiol & Virol, Dusseldorf, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
fascicolo: 5, volume: 18, anno: 2001,
pagine: 433 - 436
SICI:
0924-8579(200111)18:5<433:MSOMTA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREVALENCE; MUTATIONS; DETERMINANTS; STRAINS;
Keywords:
Streptococcus pneumomiae; macrolide resistance; penicillin resistance; tetracycline resistance; quinolone resistance; resistance determinant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Fluit, AC Univ Utrecht, Med Ctr, Eijkman Winkler Inst, Room G04-614,POB 85500, NL-3508 GA Utrecht, Netherlands Univ Utrecht Room G04-614,POB 85500 Utrecht Netherlands NL-3508 GA
Citazione:
F.J. Schmitz et al., "Molecular surveillance of macrolide, tetracycline and quinolone resistancemechanisms in 1191 clinical European Streptococcus pneumoniae isolates", INT J ANT A, 18(5), 2001, pp. 433-436

Abstract

Streptococcus pneumoniae isolates (n = 1191) were collected during a 1997-1999 European surveillance study. In addition to susceptibility data, a molecular epidemiological survey of their mechanisms of resistance to macrolides, tetracyclines, and quinolones was provided. Of the isolates tested, 72.6% were penicillin-susceptible, 19.9% penicillin-intermediate and 7.5% penicillin-resistant. There was an obvious relationship between resistance to penicillin and resistance to erythromycin (19% of all isolates), clindamycin(14%) and tetracycline (23%). Only one isolate was resistant to levofloxacin. Seventy-three percent of the European S. pneumoniae isolates resistant to erythromycin (n = 229) carried the erm(B) gene, while the remaining 27% possessed the mef(A) gene. No mutations were detected in 23S rRNA or in ribosomal proteins L4 and L22. All tetracycline-resistant isolates (n = 277) carried the tet(M) gene; none carried the tet(O) gene. Classical mutations in gyrA (Ser 81-Phe or Tyr) and parC (Ser 79-Phe and Asp 83-Asn) and efflux contributed to the decreased quinolone susceptibility. This study of recentEuropean S. pneumoniae isolates can be used to recognize any changes in susceptibility patterns and resistance mechanisms that may occur in the future. (C) 2001 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 21:18:37