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Titolo:
Does leptin stimulate nitric oxide to oppose the effects of sympathetic activation?
Autore:
Mitchell, JL; Morgan, DA; Correia, MLG; Mark, AL; Sivitz, WI; Haynes, WG;
Indirizzi:
Univ Iowa, Coll Med, Dept Internal Med, Iowa City, IA 52242 USA Univ IowaIowa City IA USA 52242 pt Internal Med, Iowa City, IA 52242 USA Univ Iowa, Coll Med, Hypertens Genet Specialized Ctr Res, Iowa City, IA USA Univ Iowa Iowa City IA USA Genet Specialized Ctr Res, Iowa City, IA USA Univ Iowa, Coll Med, Ctr Cardiovasc, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 Ctr Cardiovasc, Iowa City, IA 52242 USA Univ Iowa, Coll Med, Diabet Endocrine Res Ctr, Iowa City, IA USA Univ Iowa Iowa City IA USA , Diabet Endocrine Res Ctr, Iowa City, IA USA Vet Affairs Med Ctr, Iowa City, IA 52242 USA Vet Affairs Med Ctr Iowa City IA USA 52242 d Ctr, Iowa City, IA 52242 USA
Titolo Testata:
HYPERTENSION
fascicolo: 5, volume: 38, anno: 2001,
pagine: 1081 - 1086
SICI:
0194-911X(200111)38:5<1081:DLSNOT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; OB/OB MICE; OBESE GENE; HYPERTENSION; EXPRESSION; WEIGHT; RATS;
Keywords:
obesity; blood flow; nervous system, sympathetic renal; blood pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Haynes, WG Univ Iowa, Coll Med, Dept Internal Med, Iowa City, IA 52242 USAUniv Iowa Iowa City IA USA 52242 Med, Iowa City, IA 52242 USA
Citazione:
J.L. Mitchell et al., "Does leptin stimulate nitric oxide to oppose the effects of sympathetic activation?", HYPERTENSIO, 38(5), 2001, pp. 1081-1086

Abstract

Leptin decreases appetite and increases sympathetic nerve activity and arterial pressure. Recent reports suggest that leptin may also have peripheralvasodilator actions that would tend to reduce arterial pressure. We testedthe hypothesis that the direct vascular actions of leptin oppose sympathetically mediated vasoconstriction. We evaluated the effects of intravenous leptin (1 mg/kg over 3 hours) on arterial pressure and mesenteric, hindlimb,and renal blood flows in conscious rats. We then tested whether blockade of nitric oxide or the sympathetic nervous system would unmask a pressor or depressor effect of leptin, consistent with direct vascular actions. Acute intravenous administration of leptin alone did not change arterial pressureor regional blood flows. This was despite a significant increase in lumbarsympathetic nerve activity. Administration of the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester significantly increased arterial pressure and caused vasoconstriction. However, leptin did not have any significant effect on hemodynamics in the presence of N-G-nitro-L-arginine methyl ester despite continued sympathoactivation. a-Adrenoceptor blockade with prazosin alone or combined with yohimbine significantly decreased arterial pressure and caused vasodilation. Again, leptin did not have any effect on arterial pressure or regional blood flow in the presence of sympathetic blockade. These data demonstrate that leptin does not have vasodilator actionsin vivo at concentrations that are sufficient to increase sympathetic nerve activity. The absence of a pressor effect of leptin-induced sympathetic activation may merely reflect the brief duration of leptin administration. These data support the concept that the chronic hemodynamic actions of leptin are likely to be related to sympathetic activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:32:05