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Titolo:
Acute gender-specific hemodynamic and inotropic effects of 17 beta-estradiol on rats
Autore:
Beyer, ME; Yu, G; Hanke, H; Hoffmeister, HM;
Indirizzi:
Univ Tubingen, Med Klin, Abt 3, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 Abt 3, D-72076 Tubingen, Germany Univ Ulm, Abt 2, Med Klin, Ulm, Germany Univ Ulm Ulm GermanyUniv Ulm, Abt 2, Med Klin, Ulm, Germany
Titolo Testata:
HYPERTENSION
fascicolo: 5, volume: 38, anno: 2001,
pagine: 1003 - 1010
SICI:
0194-911X(200111)38:5<1003:AGHAIE>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATHEROSCLEROTIC CORONARY-ARTERIES; ESTROGEN-RECEPTOR; NITRIC-OXIDE; POSTMENOPAUSAL WOMEN; CARDIOVASCULAR-DISEASE; HEART-DISEASE; ACETYLCHOLINE; ENDOTHELIUM; RESPONSES; THERAPY;
Keywords:
estrogen; receptors, estrogen; nitric oxide; hemodynamics; contractility; rats, Wistar;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Beyer, ME Univ Tubingen, Med Klin, Abt 3, Otfried Muller Str 10, D-72076 Tubingen, Germany Univ Tubingen Otfried Muller Str 10 Tubingen Germany D-72076 ny
Citazione:
M.E. Beyer et al., "Acute gender-specific hemodynamic and inotropic effects of 17 beta-estradiol on rats", HYPERTENSIO, 38(5), 2001, pp. 1003-1010

Abstract

Estrogen has cardioprotective effects. In addition to beneficial effects on lipid metabolism, estrogen affects the vascular tone and may reduce endothelial dysfunction. In the present study, we examined acute gender-specifichemodynamic and inotropic effects of 17 beta -estradiol (17 beta -E) versus the control situation in open-chest rats. In addition to measurements in the intact circulation, myocardial function was examined on the basis of isovolumic registration independent of peripheral vascular effects. Regardingthe dose-dependent and gender-specific effects of 17 beta -E, in female rats, 17 beta -E (50, 100, or 200 ng/kg) increased cardiac output (CO) (26%, 43%, and 59% versus control animals) as a result of reduction in total peripheral resistance (TPR) (-13%, -18%, and -24%) without any effect on myocardial contractility (isovolumic left ventricular systolic pressure, -1%, 0%,and -6%). These vascular effects are less pronounced in male rats (for 200ng/kg 17 beta -E: CO, 34%; TPR, -14%). We investigated gender-specific effects of 200 ng/kg 17 beta -E after pretreatment with the estrogen receptor (ER) antagonist ICI 182,780. ER blockade reduced the effects of estrogen infemale rats (CO, 29%; TPR, -17%) and male rats (CO, 19%; TPR, -11%). Regarding the effects of 200 ng/kg 17,beta -E after pretreatment with N-G-nitro-L-arginine methyl ester, NO synthesis inhibition completely prevented the acute vascular effects of estrogen in female rats (CO, -4%; TPR, 1%). In addition, immunohistochemical staining revealed no gender-specific differencesof the vascular ER distribution. 17 beta -E caused an acute dose-dependentand gender-specific reduction in the afterload. ERs are involved in both genders in this vasodilative effect that is mediated by NO. This NO-mediatedeffect may explain in part the cardioprotective effect of estrogen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:24:03