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Titolo:
Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex
Autore:
Otsuki, T; Furukawa, Y; Ikeda, K; Endo, H; Yamashita, T; Shinohara, A; Iwamatsu, A; Ozawa, K; Liu, JM;
Indirizzi:
NHLBI, Hematol Branch, NIH, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 , Hematol Branch, NIH, Bethesda, MD 20892 USA Jichi Med Sch, Dept Biochem, Minami Kawachi, Tochigi 3290498, Japan Jichi Med Sch Minami Kawachi Tochigi Japan 3290498 Tochigi 3290498, Japan Jichi Med Sch, Dept Biol, Minami Kawachi, Tochigi 3290498, Japan Jichi MedSch Minami Kawachi Tochigi Japan 3290498 Tochigi 3290498, Japan Jichi Med Sch, Ctr Mol Med, Dept Hematol, Minami Kawachi, Tochigi 3290498,Japan Jichi Med Sch Minami Kawachi Tochigi Japan 3290498 Tochigi 3290498,Japan Univ Tokyo, Inst Med Sci, Div Genet Diag, Minato Ku, Tokyo 108, Japan UnivTokyo Tokyo Japan 108 , Div Genet Diag, Minato Ku, Tokyo 108, Japan Kirin Brewery Co Ltd, Cent Labs Key Technol, Sect Prot Chem, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Kirin Brewery Co Ltd Yokohama Kanagawa Japan 2360004 agawa 2360004, Japan
Titolo Testata:
HUMAN MOLECULAR GENETICS
fascicolo: 23, volume: 10, anno: 2001,
pagine: 2651 - 2660
SICI:
0964-6906(20011101)10:23<2651:FAPFAW>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CYCLE ARREST; SWI-SNF COMPLEX; GROUP-C PROTEIN; SACCHAROMYCES-CEREVISIAE; TRANSCRIPTIONAL ACTIVATORS; COMPLEMENTATION ANALYSIS; GLUCOCORTICOID RECEPTOR; NUCLEAR ACCUMULATION; ALKYLATING-AGENTS; GENE-EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Liu, JM NHLBI, Hematol Branch, NIH, Bldg 10,Room 7C103,9000 Rockville Pike, Bethesda, MD 20892 USA NHLBI Bldg 10,Room 7C103,9000 Rockville Pike Bethesda MD USA 20892
Citazione:
T. Otsuki et al., "Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex", HUM MOL GEN, 10(23), 2001, pp. 2651-2660

Abstract

Fanconi anemia (FA) is a genetic disorder that predisposes to hematopoietic failure, birth defects and cancer. We identified an interaction between the FA protein, FANCA andbrm-related gene 1 (BRG1) product. BRG1 is a subunit of the SWI/SNF complex, which remodels chromatin structure through a DNA-dependent ATPase activity. FANCA was demonstrated to associate with the endogenous SWI/SNF complex. We also found a significant increase in the molecular chaperone, glucose-regulated protein 94 (GRP94) among BRG1-associated factors isolated from a FANCA-mutant cell line, which was not seen in eithera normal control cell line or the mutant line complemented by wild-type FANCA. Despite this specific difference, FANCA did not appear to be absolutely required for in vitro chromatin remodeling. Finally, we demonstrated co-localization in the nucleus between transfected FANCA and BRG1. The physiological action of FANCA on the SWI/SNF complex remains to be clarified, but our work suggests that FANCA may recruit the SWI/SNF complex to target genes, thereby enabling coupled nuclear functions such as transcription and DNA repair.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:33:50