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Titolo:
Brief visual stimulation allows mapping of ocular dominance in visual cortex using fMRI
Autore:
Goodyear, BG; Menon, RS;
Indirizzi:
John P Robarts Res Inst, Lab Funct Magnet Resonance Res, London, ON N6A 5K8, Canada John P Robarts Res Inst London ON Canada N6A 5K8 ndon, ON N6A 5K8, Canada
Titolo Testata:
HUMAN BRAIN MAPPING
fascicolo: 4, volume: 14, anno: 2001,
pagine: 210 - 217
SICI:
1065-9471(200112)14:4<210:BVSAMO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL ARCHITECTURE; INTRINSIC SIGNALS; TECHNIQUES REVEAL; PINWHEEL CENTERS; STRIATE CORTEX; COLUMNS; MICROARCHITECTURE; ARRANGEMENT; MRI;
Keywords:
biology; brain; diagnostic imaging; neurosciences; ophthalmology; physiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Goodyear, BG Foothills Med Ctr, Seaman Family MR Res Ctr, 1403 29th St NW,Calgary, AB T2N 2T9, Canada Foothills Med Ctr 1403 29th St NW Calgary AB Canada T2N 2T9 a
Citazione:
B.G. Goodyear e R.S. Menon, "Brief visual stimulation allows mapping of ocular dominance in visual cortex using fMRI", HUM BRAIN M, 14(4), 2001, pp. 210-217

Abstract

We have used high spatial resolution (0.55 mm x 0.55 mm) functional magnetic resonance imaging (fMRI) to show that when stimulus duration is brief (<6 sec), the hyperoxic hemodynamic response to neural activity can resolve the columnar architecture of ocular dominance within the primary visual cortex of humans. Our fMRI maps of ocular dominance columns are strikingly similar in appearance, size, and orientation to those reported in the literature using optical imaging of intrinsic signals (OIS) in animal cortex and histology of post-mortem human specimens. We also demonstrate that under briefvisual stimulation conditions, our results are consistent over repeated experiments. This is not the case for long duration stimuli (greater than or equal to 10 sec). A simulated random data set exhibited the same response properties as maps obtained when using these prolonged visual stimuli. Our results suggest that brief visual stimulation is essential for fMRI to successfully resolve ocular dominance columns using the hyperoxic phase of the hemodynamic response to neural activity at our prescribed spatial resolution. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:25:18