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Titolo:
Prognostic significance of cardiac I-123 metaiodobenzylguanidine imaging for mortality and morbidity in patients failure: a prospective with chronic heart study
Autore:
Ogita, H; Shimonagata, T; Fukunami, M; Kumagai, K; Yamada, T; Asano, Y; Hirata, A; Asai, M; Kusuoka, H; Hori, M; Hoki, N;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 erapeut, Suita, Osaka 5650871, Japan Osaka Prefecture Gen Hosp, Div Cardiol, Sumiyoshi Ku, Osaka 5588558, JapanOsaka Prefecture Gen Hosp Osaka Japan 5588558 i Ku, Osaka 5588558, Japan Osaka Natl Hosp, Dept Clin Invest, Osaka, Japan Osaka Natl Hosp Osaka Japan a Natl Hosp, Dept Clin Invest, Osaka, Japan
Titolo Testata:
HEART
fascicolo: 6, volume: 86, anno: 2001,
pagine: 656 - 660
SICI:
1355-6037(200112)86:6<656:PSOCIM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC DILATED CARDIOMYOPATHY; NERVOUS ACTIVITY; NOREPINEPHRINE; PLASMA;
Keywords:
chronic heart failure; sudden death; cardiac adrenergic nerve activity;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Ogita, H Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 5650871, Japan
Citazione:
H. Ogita et al., "Prognostic significance of cardiac I-123 metaiodobenzylguanidine imaging for mortality and morbidity in patients failure: a prospective with chronic heart study", HEART, 86(6), 2001, pp. 656-660

Abstract

Objective-To determine whether cardiac iodine-123 metaiodobenzylguanidine (I-123 MIBG) imaging is useful in predicting the prognosis of patients withchronic heart failure. Design-Cardiac I-123 MIBG imaging was done on entry to the study. The cardiac MIBG washout rate was calculated from anterior chest view images obtained 20 and 200 minutes after injection of the isotope. Study patients were divided into two groups with washout rates above and below 27% (the mean value + 2 SD obtained in 20 normal subjects), and were then followed up. Setting-Tertiary referral centre. Patients-79 patients with chronic heart failure in whom the left ventricular ejection fraction was less than 40%. Results-There were 37 patients in group 1 (washout rate of greater than orequal to 27%) and 42 in group 2 (< 27%). During a follow up period of between 1 and 52 months, eight patients died suddenly and five died of worsening heart failure in group 1, while none died in group 2; 13 patients in group 1 and four in group 2 were admitted to hospital for progressive heart failure. Kaplan-Meier analysis showed that group 1 had a significantly higher mortality and morbidity (p = 0.001 and p < 0.001, respectively) than group 2. Conclusions-Cardiac I-123 MIBG washout rate seems to be a good predictor of prognosis in patients with chronic heart failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 19:35:36