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Titolo:
Development of a new method for assessing the cardiac baroreflex: responseto downward tilting in patients with diabetes mellitus
Autore:
Nakagawa, M; Takahashi, N; Ooie, T; Yufu, K; Hara, M; Watanabe, M; Nobe, S; Yonemochi, H; Katsuragi, I; Okeda, T; Sakata, T; Saikawa, T;
Indirizzi:
Oita Med Univ, Dept Lab Med, Oita 8795593, Japan Oita Med Univ Oita Japan 8795593 Univ, Dept Lab Med, Oita 8795593, Japan Oita Med Univ, Dept Internal Med 1, Oita 8795593, Japan Oita Med Univ Oita Japan 8795593 ept Internal Med 1, Oita 8795593, Japan
Titolo Testata:
HEART
fascicolo: 6, volume: 86, anno: 2001,
pagine: 643 - 648
SICI:
1355-6037(200112)86:6<643:DOANMF>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE-VARIABILITY; POWER SPECTRAL-ANALYSIS; MYOCARDIAL-INFARCTION; AUTONOMIC NEUROPATHY; REFLEX SENSITIVITY; FREQUENCY-DOMAIN; MORTALITY; HUMANS; HYPERTENSION; DYSFUNCTION;
Keywords:
baroreflex sensitivity; downward tilting; heart rate variability; diabetes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Nakagawa, M Oita Med Univ, Dept Lab Med, 1-1 Idaigaoka, Oita 8795593, Japan Oita Med Univ 1-1 Idaigaoka Oita Japan 8795593 8795593, Japan
Citazione:
M. Nakagawa et al., "Development of a new method for assessing the cardiac baroreflex: responseto downward tilting in patients with diabetes mellitus", HEART, 86(6), 2001, pp. 643-648

Abstract

Objective-To investigate the clinical value of a new non-invasive method for assessing baroreflex sensitivity using downward tilting. Patients-34 patients with diabetes mellitus, mean (SD) age, 53.6 (11.8) years. Design-Arterial blood pressure and ECG were recorded simultaneously while the patients were on a tilt table. After 20 minutes at a 70 degrees uprighttilt, the patients were returned to the supine position at a speed of 3.2 degrees /s (downward tilting baroreflex sensitivity test, DT-BRS). A beat to beat systolic blood pressure increase associated with a corresponding lengthening of the RR interval was noted during downward tilting. Baroreflex sensitivity was also assessed using the conventional method of an intravenous injection of phenylephrine (Phe-BRS). Heart rate variability was analysedduring rest and tilting. Results-The slope of the regression line for systolic blood pressure v RR interval during downward tilting was highly correlated with Phe-BRS (r = 0.83, p < 0.0001). Both DT-BRS and Phe-BRS were correlated with the high frequency (HF) component of resting heart rate variability (p < 0.005) and withthe ratio of the low frequency to the high frequency component (LF/HF) during upright tilting (p < 0.005). DT-BRS and Phe-BRS were also correlated with the difference between rest and tilting values of HF and LF/HF (p < 0.005). Conclusions-DT-BRS provides a physiological, non-invasive method for determining baroreflex sensitivity and may be a useful index of reflex cardiac vagal and sympathetic function in patients with diabetes mellitus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 17:23:17