Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Left ventricular remodelling and brain natriuretic peptide after first myocardial infarction
Autore:
Crilley, JG; Farrer, M;
Indirizzi:
Sunderlans Royal Hosp, Dept Cardiol, Ward B22 Off, Sunderland SR4 7TP, England Sunderlans Royal Hosp Sunderland England SR4 7TP erland SR4 7TP, England
Titolo Testata:
HEART
fascicolo: 6, volume: 86, anno: 2001,
pagine: 638 - 642
SICI:
1355-6037(200112)86:6<638:LVRABN>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTOLIC DYSFUNCTION; HEART-FAILURE; A-TYPE; SURVIVAL; PREDICTION; INDICATOR; ELEVATION; SECRETION;
Keywords:
brain natriuretic peptide; wall motion index; left ventricular volume index; myocardial infarction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Crilley, JG Sunderlans Royal Hosp, Dept Cardiol, Ward B22 Off, Sunderland SR4 7TP, England Sunderlans Royal Hosp Sunderland England SR4 7TP TP, England
Citazione:
J.G. Crilley e M. Farrer, "Left ventricular remodelling and brain natriuretic peptide after first myocardial infarction", HEART, 86(6), 2001, pp. 638-642

Abstract

Objective-To investigate the relation between brain natriuretic peptide (BNP) concentrations and left ventricular remodelling characteristics after acute myocardial infarction. Design-Consecutive sample prospective cohort study. Setting-District general hospital coronary care unit in the north of England. Patients-133 initial survivors of a first myocardial infarction who received thrombolytic treatment. Interventions-Patients had transthoracic echocardiography and BNP concentrations measured at three to seven days (early) and two months (late). Main outcome measures-Wall motion index less than or equal to 1.2, end systolic left ventricular volume index and mortality at one year. Results-Patients with an early wall motion index of less than or equal to 1.2 had higher early and late BNP concentrations (early BNP mean (SEM) 629 (76.2) pg/ml v 334 (20.8) pg/ml, p = 0.001 and late BNP 584 (79.5) pg/ml v 343 (25.0) pg/ml, p = 0.001). Patients with an increase in end systolic left ventricular volume index of > 10% also had higher early and late BNP concentrations (early BNP p = 0.034 and late BNP p = 0.001). Early BNP was significantly associated with one year mortality (p = 0.003). Conclusions-Higher BNP concentrations early after first myocardial infarction are associated with adverse left ventricular remodelling characteristics. This may help explain why BNP is such a strong predictor of outcome after myocardial infarction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 03:12:05