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Titolo:
Oligodendrocytes use lactate as a source of energy and as a precursor of lipids
Autore:
Sanchez-Abarca, LI; Tabernero, A; Medina, JM;
Indirizzi:
Univ Salamanca, Fac Farm, Dept Bioquim & Biol Mol, E-37007 Salamanca, Spain Univ Salamanca Salamanca Spain E-37007 iol Mol, E-37007 Salamanca, Spain Hosp Univ Salamanca, Unidad Invest, Salamanca, Spain Hosp Univ Salamanca Salamanca Spain ca, Unidad Invest, Salamanca, Spain
Titolo Testata:
GLIA
fascicolo: 3, volume: 36, anno: 2001,
pagine: 321 - 329
SICI:
0894-1491(200112)36:3<321:OULAAS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE-UTILIZATION; PRIMARY CULTURE; ALTERNATIVE PATHWAYS; BRAIN ASTROCYTES; NEWBORN RAT; NEURONS; CELL; METABOLISM; GLYCOGEN; INVITRO;
Keywords:
brain; glucose; metabolism; type 2 astrocytes; lipid synthesis; oxidation; neurons;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Medina, JM Univ Salamanca, Fac Farm, Dept Bioquim & Biol Mol, Edif Dept,Plaza Doctores Reina S-N, E-37007 Salamanca, Spain Univ Salamanca Edif Dept,Plaza Doctores Reina S-N Salamanca Spain E-37007
Citazione:
L.I. Sanchez-Abarca et al., "Oligodendrocytes use lactate as a source of energy and as a precursor of lipids", GLIA, 36(3), 2001, pp. 321-329

Abstract

Lactate is an important metabolic substrate for the brain during the postnatal period and also plays a crucial role in the traffic of metabolites between astrocytes and neurons. However, to date there are no clues with regard to lactate utilization by oligodendrocytes, the myelin-forming cells in the brain. In the present work, lactate utilization by oligodendrocytes in culture was investigated and compared with its utilization by cultured neurons, type 1 and type 2 astrocytes. Our results clearly indicate that oligodendrocytes readily use lactate both as a metabolic fuel and as a precursor to build carbon skeletons. Oligodendrocytes oxidize lactate at a higher ratethan that observed for neurons and astrocytes, and their rate of lipid synthesis from lactate was at least 6-fold higher than that found in astrocytes or neurons. The rate of glucose utilization through different pathways was also investigated. The flux of glucose through the pentose phosphate pathway and the rate of lipid synthesis were at least 2-fold higher in oligodendrocytes than in astrocytes or neurons. These findings indicate that oligodendrocyte metabolism is designed specifically for the synthesis of lipids, presumably those of myelin. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:06:40