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Titolo:
Olfactory receptor axons influence the development of glial potassium currents in the antennal lobe of the moth Manduca sexta
Autore:
Lohr, C; Oland, LA; Tolbert, LP;
Indirizzi:
Univ Kaiserslautern, Abt Allgemeine Zool, D-67653 Kaiserslautern, Germany Univ Kaiserslautern Kaiserslautern Germany D-67653 iserslautern, Germany Univ Arizona, Arizona Res Labs, Div Neurobiol, Tucson, AZ 85721 USA Univ Arizona Tucson AZ USA 85721 abs, Div Neurobiol, Tucson, AZ 85721 USA
Titolo Testata:
GLIA
fascicolo: 3, volume: 36, anno: 2001,
pagine: 309 - 320
SICI:
0894-1491(200112)36:3<309:ORAITD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LABIAL PIT ORGAN; CHANNEL EXPRESSION; ION CHANNELS; PATCH-CLAMP; SCHWANN-CELLS; EMBRYONIC NEURONS; NERVOUS-SYSTEM; K+ CURRENTS; ASTROCYTES; GLOMERULI;
Keywords:
glial cells; glomeruli; olfaction; insect; patch clamp; ionic current;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Lohr, C Univ Kaiserslautern, Abt Allgemeine Zool, Postfach 3049, D-67653 Kaiserslautern, Germany Univ Kaiserslautern Postfach 3049 Kaiserslautern Germany D-67653
Citazione:
C. Lohr et al., "Olfactory receptor axons influence the development of glial potassium currents in the antennal lobe of the moth Manduca sexta", GLIA, 36(3), 2001, pp. 309-320

Abstract

In the olfactory (antennal) lobe of the moth Manduca. sexta, olfactory receptor axons strongly influence the distribution and morphology of glial cells. In the present study, we asked whether the development of the electrophysiological properties of the glial cells is influenced by the receptor axons. Whole-cell currents were measured in antennal lobe glial cells in acutebrain slices prepared from animals at different stages of metamorphic development (stages 3, 6, and 12). Outward currents were induced by depolarizing voltage steps from a holding potential of -70 mV. At all developmental stages investigated, the outward currents were partly blocked by bath application of the potassium channel blocker 4-aminopyridine (4AP, 10 mM) or by including tetraethylammonium (TEA, 30 mM) in the pipette solution. The relative contribution of the 4AP-sensitive current to the outward current increased from 18% at stages 3 and 6 to 42% at stage 12, while the TEA-sensitive current increased from 18% at stage 3 to 81% at stage 6, and then declined again to 40% at stage 12. In contrast, in the absence of receptor axons, these changes in the contribution of the TEA- and 4AP-sensitive currents to the total outward current did not occur; rather, the current profile remainedin the most immature state (stage 3). The results suggest that olfactory receptor axons are essential for development of the mature pattern of glial potassium currents. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:11:38