Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Expression of 27 kDa heat shock protein (Hsp27) in immature rat brain after a cortical aspiration lesion
Autore:
Sanz, O; Acarin, L; Gonzalez, B; Castellano, B;
Indirizzi:
Autonomous Univ Barcelona, Fac Med, Dept Cell Biol Physiol & Immunol, UnitHistol, E-08193 Bellaterra, Spain Autonomous Univ Barcelona Bellaterra Spain E-08193 193 Bellaterra, Spain
Titolo Testata:
GLIA
fascicolo: 3, volume: 36, anno: 2001,
pagine: 259 - 270
SICI:
0894-1491(200112)36:3<259:EO2KHS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-B-CRYSTALLIN; FIBROBLAST GROWTH-FACTOR; INDUCED CELL-DEATH; DEVELOPMENTAL EXPRESSION; NERVOUS-SYSTEM; STRESS GENES; TNF-ALPHA; GLUTATHIONE; ASTROCYTES; INDUCTION;
Keywords:
astrocytes; brain injury; Hsp27; microglia; postnatal development; stress response; vimentin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Acarin, L Autonomous Univ Barcelona, Fac Med, Dept Cell Biol Physiol & Immunol, UnitHistol, E-08193 Bellaterra, Spain Autonomous Univ Barcelona Bellaterra Spain E-08193 erra, Spain
Citazione:
O. Sanz et al., "Expression of 27 kDa heat shock protein (Hsp27) in immature rat brain after a cortical aspiration lesion", GLIA, 36(3), 2001, pp. 259-270

Abstract

The 27 kDa heat shock protein (Hsp27) is a well-known member of the astroglial response to injury, playing a protective role against oxidative stress, apoptosis, and cytoskeletal destruction. Although several studies have been focused on the damaged adult brain, little is known about Hsp27 expression in the immature brain. In this work, we have examined the spatiotemporalpattern of Hsp27 expression in the normal postnatal rat brain following a cortical aspiration lesion at postnatal day 9. In the immature brain, Hsp27is mainly observed in the internal capsule, although some scattered cells are also found in the ependyma, the corpus callosum, the septum, and hypothalamic glia limitans. In the internal capsule, Hsp27 expression is developmentally regulated, being significantly decreased from postnatal day 14. After a cortical aspiration lesion, de novo expression of Hsp27 is observed incortical injured areas as well as in the secondary affected thalamus. In the cortex, expression of Hsp27 is first seen at day 1 postlesion (PL) surrounding the neurodegenerative area, becoming restricted to the glial scar atlonger survival times. Although a pulse-like expression of Hsp27 is observed in some microglial cells at day 1 PL, most Hsp27-labeled cells are reactive astrocytes, which show GFAP overexpression and coexpress vimentin from day 3 PL. In the thalamus, astroglial Hsp27 expression is delayed, being first observed at day 5 PL. Thalamic Hsp27-labeled astrocytes do not show vimentin expression. Our observations demonstrate astroglial expression of Hsp27 in areas of tissue damage following postnatal traumatic injury, suggesting an involvement of this cytoskeleton-stabilizing protein in the remodeling processes following postnatal brain damage. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:22:26