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Titolo:
Binding of human clusterin by Staphylococcus epidermidis
Autore:
Li, DQ; Ljungh, A;
Indirizzi:
Lund Univ, Dept Med Microbiol Dermatol & Infect, S-22362 Lund, Sweden LundUniv Lund Sweden S-22362 ol Dermatol & Infect, S-22362 Lund, Sweden
Titolo Testata:
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
fascicolo: 3, volume: 31, anno: 2001,
pagine: 197 - 202
SICI:
0928-8244(200110)31:3<197:BOHCBS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
VON-WILLEBRAND-FACTOR; AUREUS; RECEPTOR; PROTEIN; FIBRONECTIN; VITRONECTIN; COMPLEMENT; SURFACE; EXPRESSION; FIBRINOGEN;
Keywords:
clusterin; ligand-receptor interaction; Staphylococcus epidermidis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Ljungh, A Lund Univ, Dept Med Microbiol Dermatol & Infect, Solvegatan 23, S-22362 Lund, Sweden Lund Univ Solvegatan 23 Lund Sweden S-22362 -22362 Lund, Sweden
Citazione:
D.Q. Li e A. Ljungh, "Binding of human clusterin by Staphylococcus epidermidis", FEMS IM MED, 31(3), 2001, pp. 197-202

Abstract

To hypothesise that Staphylococcus epidermidis may possess clusterin receptor(s), bacterial binding of human clusterin was determined. In a fluid phase, the binding was markedly influenced by culture medium and three out of 12 S. epidermidis strains grown on ISO-sensitest agar expressed clusterin-binding ability. S. epidermidis J9P, selected for further study, showed saturable binding of iodine-labelled clusterin, and the binding was only inhibited by unlabelled clusterin. The binding was sensitive to protease treatment. Scatchard plot indicated one single class of binding sites (K-d = 104.2 nM). None of the S. epidermidis strains bound immobilised clusterin. These data imply that ligand-receptor interaction exists between S. epidermidis and clusterin in fluid phase, but the domain(s) recognised by bacteria may have been occluded when clusterin was adsorbed on a surface. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B. V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:31:06