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Titolo:
The serine protease inhibitor antithrombin III inhibits LPS-mediated NF-kappa B activation by TLR-4
Autore:
Mansell, A; Reinicke, A; Worrall, DM; ONeill, LAJ;
Indirizzi:
Univ Dublin Trinity Coll, Dept Biochem, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 ept Biochem, Dublin 2, Ireland Univ Dublin Trinity Coll, Inst Biotechnol, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 Biotechnol, Dublin 2, Ireland Natl Univ Ireland Univ Coll Dublin, Dept Biochem, Dublin 4, Ireland Natl Univ Ireland Univ Coll Dublin Dublin Ireland 4 m, Dublin 4, Ireland
Titolo Testata:
FEBS LETTERS
fascicolo: 3, volume: 508, anno: 2001,
pagine: 313 - 317
SICI:
0014-5793(20011123)508:3<313:TSPIAI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR SUPERFAMILY; HOST-DEFENSE; SIGNAL-TRANSDUCTION; DROSOPHILA; RECOGNITION; GENE; LIPOPOLYSACCHARIDE; INFLAMMATION; MECHANISMS; MUTATIONS;
Keywords:
lipopolysaccharide; inflammation; signal transduction; monocyte; transcription factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: O'Neill, LAJ Univ Dublin Trinity Coll, Dept Biochem, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 Dublin 2, Ireland
Citazione:
A. Mansell et al., "The serine protease inhibitor antithrombin III inhibits LPS-mediated NF-kappa B activation by TLR-4", FEBS LETTER, 508(3), 2001, pp. 313-317

Abstract

In Drosophila, the Toll family of proteins mediates the innate immune response. Toll is activated by Spaetzle, which is generated in response to pathogens via a serine protease cascade. We wished to investigate if lipopolysaccharides (LPS) might activate Toll-like receptor (TLR) 4 via a scrine protease in humans. The serpin antithrombin III (ATIII) and the thrombin inhibitor hirudin both inhibited nuclear factor (NF)-kappaB activation by LPS andLipid A. ATIII and hirudin were also able to inhibit LPS-induced NF-kappaBactivation in cells stably transfected with TLR4. These results suggest that LPS may activate a mammalian serine protease, which generates a product required for TLR4 signalling. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 14:44:16