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Titolo:
Trichuris suis: Detection of antibacterial activity in excretory-secretoryproducts from adults
Autore:
Abner, SR; Parthasarathy, G; Hill, DE; Mansfield, LS;
Indirizzi:
Michigan State Univ, Coll Vet Med, Natl Food Safety & Toxicol Ctr, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 l Ctr, E Lansing, MI 48824 USA ARS, USDA, Beltsville, MD USA ARS Beltsville MD USAARS, USDA, Beltsville, MD USA
Titolo Testata:
EXPERIMENTAL PARASITOLOGY
fascicolo: 1, volume: 99, anno: 2001,
pagine: 26 - 36
SICI:
0014-4894(200109)99:1<26:TSDOAA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
RICH ANTIMICROBIAL PEPTIDE; NEMATODE ASCARIS-SUUM; CDNA CLONING; BOMBYX-MORI; PHYSICOCHEMICAL PROPERTIES; ENTAMOEBA-HISTOLYTICA; PURIFICATION; TRANSPORT; SILKWORM; PROTEIN;
Keywords:
Trichuris suis; nematode; antibacterial; Campylobacter jejuni; Campylobacter coli; Escherichia coli; Staphylococcus aureus; Enterococcus faecalis; Pseudomonas aeruginosa; Streptococcus pneumoniae;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Abner, SR Ctr Dis Control & Prevent, Atlanta, GA 30333 USA Ctr Dis Control& Prevent Atlanta GA USA 30333 ta, GA 30333 USA
Citazione:
S.R. Abner et al., "Trichuris suis: Detection of antibacterial activity in excretory-secretoryproducts from adults", EXP PARASIT, 99(1), 2001, pp. 26-36

Abstract

Antibacterial activity was detected in excretory-secretory products (ESP) of adult Trichuris suis cultured in vitro in serum-free media. Gram-negative bacteria (Campylobacter jejuni, Campylobacter call, and Escherichia colt)and Gram-positive bacteria (Staphylococcus aureus) were sensitive to ESR Susceptibility was dependent on the concentration, of ESP but not on the inoculum size. Preliminary assessment of the mode of action suggests a bacteriocidal mechanism. This antibacterial activity was heat stable and resistantto digestion with pronase E and trypsin. Based on ultrafiltration experiments, the activity is less than 10,000 MW. This excreted/secreted antibacterial activity from T. suis, is likely a component of a humoral defense system for this helminth. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:52:07