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Titolo:
Epileptiform activity in the nucleus accumbens induced by GABA(A) receptorantagonists in rat forebrain slices is of cortical origin
Autore:
Buckby, LE; Lacey, MG;
Indirizzi:
Univ Birmingham, Sch Med, Dept Pharmacol, Div Neurosci, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT W Midlands, England
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 2, volume: 141, anno: 2001,
pagine: 146 - 152
SICI:
0014-4819(200111)141:2<146:EAITNA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIRIFORM CORTEX; SYNAPTIC TRANSMISSION; IN-VITRO; IDENTIFIED NEURONS; DOPAMINE; PROPAGATION; INVITRO; EPILEPTOGENESIS; STIMULATION; HIPPOCAMPAL;
Keywords:
nucleus accumbens; field EPSP; GABA(A) antagonists; epileptiform activity; cerebral cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Lacey, MG Univ Birmingham, Sch Med, Dept Pharmacol, Div Neurosci, Vincent Dr, Birmingham B15 2TT, W Midlands, England Univ Birmingham Vincent Dr Birmingham W Midlands England B15 2TT
Citazione:
L.E. Buckby e M.G. Lacey, "Epileptiform activity in the nucleus accumbens induced by GABA(A) receptorantagonists in rat forebrain slices is of cortical origin", EXP BRAIN R, 141(2), 2001, pp. 146-152

Abstract

Extracellularly recorded field potentials, evoked by stimulation of cortico-nucleus accumbens border, were recorded in the nucleus accumbens (NAcc) in horizontal slices of rat ventral forebrain. The field excitatory postsynaptic potential (EPSP) event (N2) was calcium dependent, blocked by tetrodotoxin (1 muM), and reduced by over 70% by 6-cyano-7-nitroquinoxaline-2,3dione (CNQX) (10 muM). the antagonist of AMPA-type glutamate receptors. The EPSP amplitude was enhanced by either of the GABA,, receptor antagonists, picrotoxin ( 10 muM; by 252 +/- 33%, n=18) and bicuculline methiodide (20 muM by 216 +/- 34%, n=4). Additionally, picrotoxin (3-50 muM) and bicuculline methiodide (20 muM) promoted epileptiform activity within the NAcc, manifest as the emergence of additional late components. N3, N4 and N5, in the evoked synaptic waveform. fn slices with the frontal cortex removed, picrotoxin (10-50 muM) and bicuculline methiodide (20 muM) were unable to promote epileptiform activity within the NAcc. although a smaller increase in the peak amplitude of the field EPSP ( 163 +/- 18%, n=6) was observed at the highestconcentrations of picrotoxin (50 muM). Histological examination of the slice demonstrated that in such decorticated slices, the piriform cortex (PC) had been removed. We propose that stimulation of the cortico-NAcc border not only evokes an orthodromic EPSP in the NAcc, but also causes antidromic activation of cortical tissue. Disinhibition by GABA(A) antagonists of circuits intrinsic to the cortex, possibly the piriform cortex. is the principalcause of the facilitation of the EPSP and of regenerative epileptiform activity in NAcc evoked by stimulation of cortical input.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:08:05