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Titolo:
Recovery period of the bladder after exposure to soluble virulence factor produced by Escherichia coli
Autore:
Aslan, G; Esen, N; Esen, AA; Koyuncuoglu, M; Celebi, H; Yulug, N;
Indirizzi:
Dokuz Eylul Univ, Sch Med, Dept Urol, TR-35340 Izmir, Turkey Dokuz Eylul Univ Izmir Turkey TR-35340 Dept Urol, TR-35340 Izmir, Turkey Dokuz Eylul Univ, Sch Med, Dept Microbiol, TR-35340 Izmir, Turkey Dokuz Eylul Univ Izmir Turkey TR-35340 Microbiol, TR-35340 Izmir, Turkey Dokuz Eylul Univ, Sch Med, Dept Pathol, TR-35340 Izmir, Turkey Dokuz EylulUniv Izmir Turkey TR-35340 pt Pathol, TR-35340 Izmir, Turkey
Titolo Testata:
EUROPEAN UROLOGY
fascicolo: 4, volume: 40, anno: 2001,
pagine: 446 - 450
SICI:
0302-2838(200110)40:4<446:RPOTBA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOSAMINOGLYCAN SODIUM PENTOSANPOLYSULFATE; EPITHELIAL PERMEABILITY BARRIER; PROTAMINE SULFATE; SURFACE GLYCOSAMINOGLYCANS; INFECTION; RATS;
Keywords:
Escherichia coli; soluble virulence factor; bladder recovery; epithelium; glycosaminoglycans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Esen, AA Dokuz Eylul Univ, Sch Med, Dept Urol, TR-35340 Izmir, Turkey Dokuz Eylul Univ Izmir Turkey TR-35340 , TR-35340 Izmir, Turkey
Citazione:
G. Aslan et al., "Recovery period of the bladder after exposure to soluble virulence factor produced by Escherichia coli", EUR UROL, 40(4), 2001, pp. 446-450

Abstract

Objectives:This study was designed to determine the time interval requiredfor the recovery of the bladder after exposure to soluble virulence factor(SVF) in an animal model. In addition, we aimed to determine the changes in the epithelium during the recovery period. Methods: A total of 46 male New Zealand rabbits were used in this study. Sterile human urine was infected with Escherichia coli type 06 to obtain supernatant, which would contain SVF, but no bacteria. Rabbits were assigned to one of three groups comprising the supernatant urine group (SUG) and controls, respectively. Sterile human urine and supernatant urine were instilled to controls and SUG, respectively. Bacterial inoculation with E. coli wasperformed 1, 24 and 72 h after initial instillation. Histopathologic and microbiologic analyses were performed on these animals. Results: In SUG bacterial colonization was significantly higher than in controls 1 and 24 h after exposure to supernatant. Histopathologic analysis confirmed this finding. Histologic changes were most pronounced 1 hour afterinstillation of supernatant. A moderate degree of recovery was noted at 24h, and complete recovery was seen at 72 h. Conclusion: Bacterial growth is potentiated by SVF-induced impaired bladder mucosa until the repairing process has been completed. During this time interval, SVF enables the colonization and growth of E. coli and other bacterium species that may result in sustained bacterial presence and recurrent infection. Copyright (C) 2001 S. Karger AG. Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:27:26