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Titolo:
Antitussive action of nociceptin in the cat
Autore:
Bolser, DC; McLeod, RL; Tulshian, DB; Hey, JA;
Indirizzi:
Univ Florida, Dept Physiol Sci, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 siol Sci, Gainesville, FL 32610 USA Schering Plough Res Inst, Kenilworth, NJ 07003 USA Schering Plough Res Inst Kenilworth NJ USA 07003 Kenilworth, NJ 07003 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 430, anno: 2001,
pagine: 107 - 111
SICI:
0014-2999(20011026)430:1<107:AAONIT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG; OPIOID RECEPTOR; COUGH REFLEX; SITES; BRONCHOCONSTRICTION; AGONISTS; DRUGS; FQ;
Keywords:
cough; antitussive; (cat); nociceptin; ORL1 receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Bolser, DC Univ Florida, Dept Physiol Sci, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 ainesville, FL 32610 USA
Citazione:
D.C. Bolser et al., "Antitussive action of nociceptin in the cat", EUR J PHARM, 430(1), 2001, pp. 107-111

Abstract

Experiments were conducted to determine the influence of the specific ORL1receptor agonist, nociceptin, on the cough reflex in the cat. Cats were anesthetized and allowed to breathe spontaneously. Cough was elicited by mechanical stimulation of the intrathoracic airway. Intravenous administration of nociceptin (0.001-3.0 mg kg(-1)) inhibited cough number and the magnitude of abdominal muscle electromyogram (EMG) discharge during cough in a dose-dependent manner. Nociceptin had no effect on the magnitude of the inspiratory muscle EMG during cough. These effects of nociceptin were antagonized-by pretreatment with the ORL1 receptor antagonist, 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1, 3-dihydro-2H-benzimidazol-2-one (J-113397, 0.1 mg kg(-1), i.v.). We conclude that intravenous nociceptininhibits cough in the cat. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 19:45:57