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Titolo:
Brain tumour imaging with carbon-11 choline: comparison with FDG PET and gadolinium-enhanced MR imaging
Autore:
Ohtani, T; Kurihara, H; Ishiuchi, S; Saito, N; Oriuchi, N; Inoue, T; Sasaki, T;
Indirizzi:
Gunma Univ, Sch Med, Dept Neurosurg, Maebashi, Gumma 3718511, Japan Gunma Univ Maebashi Gumma Japan 3718511 g, Maebashi, Gumma 3718511, Japan Gunma Univ, Sch Med, Dept Nucl Med, Maebashi, Gumma 371, Japan Gunma UnivMaebashi Gumma Japan 371 Nucl Med, Maebashi, Gumma 371, Japan
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 11, volume: 28, anno: 2001,
pagine: 1664 - 1670
SICI:
0340-6997(200111)28:11<1664:BTIWCC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; MAGNETIC-RESONANCE SPECTROSCOPY; F-18 FLUORODEOXYGLUCOSE PET; CEREBRAL GLIOMAS; C-11 CHOLINE; IN-VITRO; METHIONINE PET; CANCER; DIFFERENTIATION; VIVO;
Keywords:
brain neoplasms; carbon-11 choline; fluorine-18 fluorodeoxyglucose; magnetic resonance imaging; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Ohtani, T Gunma Univ, Sch Med, Dept Neurosurg, 3-39-22,Showa Machi, Maebashi, Gumma 3718511, Japan Gunma Univ 3-39-22,Showa Machi Maebashi Gumma Japan 3718511 apan
Citazione:
T. Ohtani et al., "Brain tumour imaging with carbon-11 choline: comparison with FDG PET and gadolinium-enhanced MR imaging", EUR J NUCL, 28(11), 2001, pp. 1664-1670

Abstract

The purpose of this study was to assess the clinical potential of methyl-C-11-choline (C-11-choline) in the diagnosis of brain tumours. To this end, the results of C-11-choline positron emission tomography (PET) in 22 patients suspected of having brain tumours were compared with the findings of contrast-enhanced magnetic resonance (MR) imaging and fluorine-18 fluorodeoxyglucose PET. A histopathological diagnosis was made for each patient during open surgery. The standardised uptake values of brain tumours and the tumour-to-white matter count (T/W) ratios were determined. The degree of C-11-choline accumulation noted in PET images was compared with the gadolinium-enhanced areas of MR images. The mean T/W ratio of 11C-choline in high-grade gliomas was found to be higher than that in low-grade gliomas. This difference was statistically significant (mean +/- SD: 8.7 +/-6.2, n=9 versus 1.5 +/-0.7, n=5, P <0.03) when data pertaining to the prominent uptake of C-11-choline in a patient with a pilocytic astrocytoma were excluded. C-11-choline PET failed to detect nonneoplastic lesions in two patients. Areas of C-11-choline accumulation in PET scans were larger than areas enhanced on MR images in five cases involving high-grade gliomas. C-11-choline PET differentiated between low-grade gliomas and high-grade gliomas, but did not differentiate between low-grade gliomas and non-neoplastic lesions. The combination of C-11-choline PET and MR imaging may provide investigators with an accurate means by which to identify high-grade gliomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:07:28