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Titolo:
Myocardial metabolism of I-123-BMIPP during low-flow ischaemia in an experimental model: comparison with myocardial blood flow and F-18-FDG
Autore:
Hosokawa, R; Nohara, R; Fujibayashi, Y; Hirai, T; Fujita, M; Magata, Y; Tadamura, E; Konishi, J; Sasayama, S;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 ovasc Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Grad Sch Med, Dept Nucl Med, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Med, Dept Nucl Med, Kyoto 6068507, Japan Fukui Med Univ, Biomed Imaging Res Ctr, Fukui, Japan Fukui Med Univ Fukui Japan d Univ, Biomed Imaging Res Ctr, Fukui, Japan
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 11, volume: 28, anno: 2001,
pagine: 1630 - 1639
SICI:
0340-6997(200111)28:11<1630:MMOIDL>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; ISCHEMIC-HEART-DISEASE; FATTY-ACID ANALOG; CANINE MYOCARDIUM; WALL-MOTION; HIBERNATING MYOCARDIUM; GLUCOSE-METABOLISM; INFARCTION; PERFUSION; IODINE-123-BMIPP;
Keywords:
I-123-BMIPP; F-18-FDG; hibernation; coronary artery disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Nohara, R Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, 54 Kawaracho, Kyoto 6068507, Japan Kyoto Univ 54 Kawaracho Kyoto Japan 6068507 yoto 6068507, Japan
Citazione:
R. Hosokawa et al., "Myocardial metabolism of I-123-BMIPP during low-flow ischaemia in an experimental model: comparison with myocardial blood flow and F-18-FDG", EUR J NUCL, 28(11), 2001, pp. 1630-1639

Abstract

Risk stratification of coronary artery disease may provide a basis for selection of treatment to prevent myocardial events and to assist functional recovery. lodine-123 (p-iodophenyl)-3-R,S-methylpentadecanoic acid (I-123-BMIPP) is a radioiodinated fatty acid analogue for single-photon emission tomographic (SPET) imaging, and several reports have demonstrated that the abnormal uptake of I-123-BMIPP is associated with wall motion abnormality and severe coronary artery stenosis. Clarification of the contribution of fattyacids to myocardial metabolism would be highly valuable in recognising this critical condition. In this study, we investigated the myocardial uptake of I-123-BMIPP under low-flow ischaemia, and compared it with the uptake offluorine-18 fluorodeoxyglucose (F-18-FDG). Using open chest dogs, the flowof the left anterior descending coronary artery was controlled using a pneumatic occluder in order to maintain a 30%-40% reduction of Doppler flow. I-123-BMIPP and 18F-FDG were injected into the left atrium after 90 min of ischaemia (protocols 1 and 3). Canine hearts were excised after 120 min of ischaemia for the measurement of radioactivity. In protocol 2, I-123-BMIPP alone was injected and hearts were excised 8 min after the injection. A time-course biopsy study was also performed at the same time (protocol 3). Wallthickening was evaluated using a wall tracker module. The uptake of F-18-FDG increased significantly in the ischaemic region (232%+/- 135% vs non-ischaemic. P <0.05 in protocol 1) even on mild reduction of myocardial blood flow (MBF). The increased uptake of F-18-FDG did not correlate well with theseverity of MBF. On the other hand, I-123-BMIPP uptake decreased gradually(78.9%+/- 23.6%, P <0.05 in protocol 1, and 85.9%+/- 24.3% in protocol 2) in the ischaemic region, specifically in the endocardium (64.0%+/- 28.9%, P<0.05 in protocol 1. and 75.1%+/- 28.8%, P<0.05 in protocol 2), and correlated strongly with MBF (r=0.93 in protocol 1 and r=0.97 in protocol 2) as alogarithmic function. This indicated that the abnormal uptake of I-123-BMIPP was associated not only with wall motion abnormality but also with the severity of MBF In the biopsy study (protocol 3), the radioactivity of either I-123-BMIPP or F-18-FDG correlated well with the MBF at the time of tracer injection and was similar to post-mortem analysis. It is concluded that F-18-FDG is a valid tool for identifying ischaemic myocardium even in its earliest stages. On the other hand, I-123-BMIPP might be used to detect moderately to severely ischaemic myocardium such as hibernation, suggesting the potential value of I-123-BMIPP in the risk stratification of patients with severe coronary artery disease who require revascularisation without delay.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:51:32