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Titolo:
Orexins (hypocretins) directly excite tuberomammillary neurons
Autore:
Bayer, L; Eggermann, E; Serafin, M; Saint-Mleux, B; Machard, D; Jones, B; Muhlethaler, M;
Indirizzi:
Ctr Med Univ Geneva, Dept Physiol, CH-1211 Geneva 4, Switzerland Ctr Med Univ Geneva Geneva Switzerland 4 , CH-1211 Geneva 4, Switzerland McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 surg, Montreal, PQ H3A 2B4, Canada
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 9, volume: 14, anno: 2001,
pagine: 1571 - 1575
SICI:
0953-816X(200111)14:9<1571:O(DETN>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT HYPOTHALAMUS INVITRO; LOCUS-COERULEUS NEURONS; RECEPTOR MESSENGER-RNA; SPINAL-CORD; DIFFERENTIAL DISTRIBUTION; HUMAN NARCOLEPSY; IN-VITRO; SLEEP; BRAIN; PEPTIDES;
Keywords:
arousal; histamine; rat; sleep; wakefulness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Muhlethaler, M Ctr Med Univ Geneva, Dept Physiol, 1 Rue Michel Servet, CH-1211 Geneva 4, Switzerland Ctr Med Univ Geneva 1 Rue Michel Servet Geneva Switzerland 4
Citazione:
L. Bayer et al., "Orexins (hypocretins) directly excite tuberomammillary neurons", EUR J NEURO, 14(9), 2001, pp. 1571-1575

Abstract

Wakefulness has recently been shown to depend upon the newly identified orexin (or hypocretin) neuropeptides by the findings that alteration in theirprecursor protein, their receptors or the neurons that produce them leads to the sleep disorder narcolepsy in both animals and humans. The questions of how and where these brain peptides act to maintain wakefulness remain unresolved. The purpose of the present study was to determine whether the orexins could directly affect hypothalamic histaminergic neurons, which are known to contribute to the state of wakefulness by their diffuse projections through the brain. Using brain slices, we recorded in the ventral tuberomammillary nuclei from neurons identified as histaminergic on the basis of their previously described morphological and electrophysiological characteristics and found that they were depolarized and excited by the orexins througha direct postsynaptic action. We then compared the depolarizing effect of orexin A and B and found that they were equally effective upon these cells. This latter finding suggests that the effect of orexins is mediated by orexin type 2 receptors, which are those lacking in narcoleptic dogs. Our results therefore show that the histaminergic neurons of the tuberomammillary nuclei represent an important target for the orexin system in the maintenance of wakefulness.

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Documento generato il 18/01/20 alle ore 10:41:32