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Titolo:
A single exposure to morphine induces long-lasting behavioural and neurochemical sensitization in rats
Autore:
Vanderschuren, LJMJ; De Vries, TJ; Wardeh, G; Hogenboom, FACM; Schoffelmeer, ANM;
Indirizzi:
Vrije Univ Amsterdam, Med Ctr, Dept Med Pharmacol, Res Inst Neurosci,Drug Abuse Program, NL-1081 BT Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1081 BT erdam, Netherlands
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 9, volume: 14, anno: 2001,
pagine: 1533 - 1538
SICI:
0953-816X(200111)14:9<1533:ASETMI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; IN-VIVO MICRODIALYSIS; NUCLEUS-ACCUMBENS; CHRONIC AMPHETAMINE; STRIATAL DOPAMINE; TREATED RATS; RELEASE; STIMULATION; COCAINE; REWARD;
Keywords:
acetylcholine release; amphetamine; caudate-putamen; dopamine release; locomotion; nucleus accumbens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Vanderschuren, LJMJ Vrije Univ Amsterdam, Med Ctr, Dept Med Pharmacol, ResInst Neurosci,Drug Abuse Program, Van der Boechorststr 7, NL-1081 BT Amsterdam, Netherlands Vrije Univ Amsterdam Van der Boechorststr 7 Amsterdam Netherlands NL-1081 BT
Citazione:
L.J.M.J. Vanderschuren et al., "A single exposure to morphine induces long-lasting behavioural and neurochemical sensitization in rats", EUR J NEURO, 14(9), 2001, pp. 1533-1538

Abstract

Repeated exposure to drugs of abuse causes persistent behavioural sensitization and associated adaptations in striatal neurotransmission, which is thought to play an important role in certain aspects of drug addiction. Remarkably, even a single exposure to psychostimulant drugs such as amphetamine or cocaine can be sufficient to elicit long-lasting sensitization. The present study was designed to evaluate whether long-lasting behavioural and neurochemical sensitization can also be evoked by a single exposure to morphine, an opiate drug of abuse. Rats were pretreated once with morphine (2, 10 or 30 mg/kg). Three weeks later, the locomotor effects of morphine and amphetamine, as well as the electrically evoked release of [H-3]dopamine and [C-14]acetylcholine from slices of nucleus accumbens and caudate-putamen, wasassessed. In morphine-p retreated rats, the psychomotor effects of morphine and amphetamine were sensitized. In addition, the electrically evoked release of [H-3]dopamine and [C-14]acetylcholine was augmented in slices of nucleus accumbens and caudate-putamen from morphine-p retreated animals. Although the sensitization of the locomotor effect of morphine was less profound than previously observed after repeated intermittent morphine treatment, the enduring behavioural and neurochemical consequences of a single and repeated intermittent morphine treatment appear to be highly comparable. We therefore conclude that a single exposure to morphine induces longlasting behavioural sensitization and associated neuroadaptations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:38:44