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Titolo:
Cardiovascular effects of sildenafil citrate (Viagra (R)): A naturalistic cross-over study
Autore:
Agelink, MW; Schmitz, T; Rembrink, K; Beckerling, D; Muck-Weymann, M; Mercik, D; Brockmeyer, NH;
Indirizzi:
Ruhr Univ Bochum, Evangl Clin Gelsenkirchen, Dept Biol Psychiat & Neurosci, D-45879 Gelsenkirchen, Germany Ruhr Univ Bochum Gelsenkirchen Germany D-45879 79 Gelsenkirchen, Germany Ruhr Univ Bochum, Evangl Clin Gelsenkirchen, Dept Urol, D-45879 Gelsenkirchen, Germany Ruhr Univ Bochum Gelsenkirchen Germany D-45879 79 Gelsenkirchen, Germany Univ Erlangen Nurnberg, Dept Physiol & Cardiol, D-8520 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-8520 D-8520 Erlangen, Germany Cent Clin Gliwice, Dept Endocrinol, Gliwice, Poland Cent Clin Gliwice Gliwice Poland wice, Dept Endocrinol, Gliwice, Poland Ruhr Univ Bochum, St Josef Hosp, Dept Dermatol & Allergol, Bochum, GermanyRuhr Univ Bochum Bochum Germany pt Dermatol & Allergol, Bochum, Germany
Titolo Testata:
EUROPEAN JOURNAL OF MEDICAL RESEARCH
fascicolo: 11, volume: 6, anno: 2001,
pagine: 459 - 464
SICI:
0949-2321(20011120)6:11<459:CEOSC(>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE-VARIABILITY; POWER SPECTRAL-ANALYSIS; AUTONOMIC NEUROPATHY; BLOOD-PRESSURE; SYMPATHOVAGAL BALANCE; MYOCARDIAL-INFARCTION; ERECTILE DYSFUNCTION; NITRIC-OXIDE; IN-VITRO; MORTALITY;
Keywords:
clinical; regulatory systems; organ; pharmacology; autonomic nervous system; heart rate variability; baroreflex; coronary disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Agelink, MW Ruhr Univ Bochum, Evangl Clin Gelsenkirchen, Dept Biol Psychiat & Neurosci, Munckelstr 27, D-45879 Gelsenkirchen, Germany Ruhr Univ Bochum Munckelstr 27 Gelsenkirchen Germany D-45879
Citazione:
M.W. Agelink et al., "Cardiovascular effects of sildenafil citrate (Viagra (R)): A naturalistic cross-over study", EUR J MED R, 6(11), 2001, pp. 459-464

Abstract

In a cross-over study we investigated the effects of sildenafil (single doses of 25- or 50mg) on cardiovascular autonomic nervous system (ANS) function assessed by serial recordings of blood pressure, conventional 12-lead electrocardiograms and standardized, time-and frequency domain indices of heart rate variability (HRV) in 21 men with erectile dysfunction. More than half of these patients had multiple comorbidities. Sildenafil induced significant mean reductions from baseline in resting blood pressure, accompanied by a reflex increase in heart rate. There were no significant changes after administration of sildenafil in any other of the ANS function indices. These preliminary findings suggest that sildenafil does not significantly affect cardiac ANS function in patients with erectile dysfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:20:54