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Titolo:
Cyclic mechanical stretching modulates secretion pattern of growth factorsin human tendon fibroblasts
Autore:
Skutek, M; van Griensven, M; Zeichen, J; Brauer, N; Bosch, U;
Indirizzi:
Hannover Med Sch, Cell Biol & Histol Lab, Dept Trauma Surg, D-30623 Hannover, Germany Hannover Med Sch Hannover Germany D-30623 urg, D-30623 Hannover, Germany
Titolo Testata:
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 86, anno: 2001,
pagine: 48 - 52
SICI:
1439-6319(200111)86:1<48:CMSMSP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TGF-BETA; IN-VITRO; CELLS; PROLIFERATION; PDGF; IMMOBILIZATION; LIGAMENTS; APOPTOSIS; STRAIN;
Keywords:
cytokines; human tendon fibroblasts; secretion pattern;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Skutek, M Hannover Med Sch, Cell Biol & Histol Lab, Dept Trauma Surg, Postbox 610180, D-30623 Hannover, Germany Hannover Med Sch Postbox 610180 Hannover Germany D-30623 ermany
Citazione:
M. Skutek et al., "Cyclic mechanical stretching modulates secretion pattern of growth factorsin human tendon fibroblasts", EUR J A PHY, 86(1), 2001, pp. 48-52

Abstract

The objective of the study was to investigate whether the response profileof the growth factor of human tendon fibroblasts could be beneficially influenced through the application of mechanical stretch. It was considered that this would elucidate structural and functional problems, often seen after tendon and ligament healing. The secretion pattern of transforming growthfactor-beta (TGF-beta), platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) was determined in mechanically stretched fibroblasts and compared to non-stretched controls. Human tendon fibroblasts were experimentally stretched for 15 and 60 min at a frequency of I Hz and anamplitude of 5%. The secretion of TGF-beta, PDGF and bFGF was measured by enzyme-linked immuno-sorbent assay. All the growth factors investigated were indeed secreted by human tendon fibroblasts both in stretched cells and controls. Mechanical stretch increased the secretion pattern of the growth factors. The increased concentrations of TGF-beta, bFGF and PDGF after cyclical mechanical stretching may have a positive influence on tendon and ligament healing through stimulation of cell proliferation, differentiation and matrix formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 21:03:00