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Titolo:
Effects of an external nasal strip and frusemide on pulmonary haemorrhage in Thoroughbreds following high-intensity exercise
Autore:
Geor, RJ; Ommundson, L; Fenton, G; Pagan, JD;
Indirizzi:
Kentucky Equine Res Inc, Versailles, KY 40383 USA Kentucky Equine Res IncVersailles KY USA 40383 Versailles, KY 40383 USA EquiGym Prod, Paris, KY 40361 USA EquiGym Prod Paris KY USA 40361EquiGym Prod, Paris, KY 40361 USA CNS Inc, Minneapolis, MN 55439 USA CNS Inc Minneapolis MN USA 55439CNS Inc, Minneapolis, MN 55439 USA
Titolo Testata:
EQUINE VETERINARY JOURNAL
fascicolo: 6, volume: 33, anno: 2001,
pagine: 577 - 584
SICI:
0425-1644(200111)33:6<577:EOAENS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY MUSCLE WORK; STRESS FAILURE; ARTERIAL-PRESSURE; MAXIMAL EXERCISE; RACING TIMES; FUROSEMIDE; HEMORRHAGE; HORSES; RACEHORSES; PERFORMANCE;
Keywords:
horse; frusemide; pulmonary haemorrhage; oxygen consumtion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Geor, RJ R&J Vet Consultants Inc, 51 Cambridge St, Guelph, ON N1H 2V1, Canada R&J Vet Consultants Inc 51 Cambridge St Guelph ON Canada N1H 2V1
Citazione:
R.J. Geor et al., "Effects of an external nasal strip and frusemide on pulmonary haemorrhage in Thoroughbreds following high-intensity exercise", EQUINE V J, 33(6), 2001, pp. 577-584

Abstract

The purpose of this study was to examine the effects of an external nasal strip (NS), frusemide (FR) and a combination of the 2 treatments (NS + FR) on exercise-induced pulmonary haemorrhage (EIPH) in Thoroughbred horses. Itwas hypothesised that both the NS and FR would attenuate EIPH as assessed by red blood cell count in bronchoalveolar lavage fluid. In random order, 8horses completed each of 4 sprint exercise tests on a treadmill: 1) NS; 2)FR (0.5 mg/kg bwt i.v., 4 h pre-exercise); 3) NS + FR; and 4) control (C; no treatment). After a 5 min warm-up (4.5 m/s), horses completed 2 min running at 120% maximum oxygen consumption ((V) over dot (O2max)) with the treadmill set at 3 degrees incline. Mean +/- s.d. running speed was 14.2 +/- 0.2 m/s. In the FR and NS + FR trials, horses carried weight equal to that lost as a result of frusemide administration. During exercise at 120% (V) over dot (O2max), oxygen consumption ((V) over dot (O2)) and carbon dioxide production ((V) over dot (CO2)) were measured at 15 s intervals. Plasma lactate concentration was measured in samples collected before exercise, at the end of the sprint and after 5 min cool-down at the trot. Thirty minutes after the run, bronchoalveolar lavage (BAL) was performed and the red cell count in the fluid quantified. (V) over dot (O2) and (V) over dot (CO2) were significantly lower in NS and NS + FR trials than in the C and FR trials at the end of the sprint exercise protocol. However, plasma lactate concentrations did not differ among treatments. Compared with the C trial (61.1 +/- 30.5 x 10(6) red blood cells/ml BAL fluid), pulmonary haemorrhage was significantly (P <0.05) decreased in both the NS (15.9 +/- 4.0 x 10(6) RBC/ml) and FR (12.2 +/- 5.8 X 10(6) RBC/ml) trials. EIPH in the NS + FR trial (7.9 +/- 1.0 X 10(6) RBC/ml) was further diminished (P <0.05) compared to the NS trial, but not different from the FR trial. We conclude that both the external nasal strip and frusemide attenuate pulmonary haemorrhage in Thoroughbred horses during high-speed sprint exercise. The external nasal strip appears to lower the metabolic cost of supramaximal exertion in horses. Given the purported ergogenic effects of frusemide, the external nasal strip is a valuable alternative for the attenuation of EIPH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:25:18