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Titolo:
Neutrophil functions and serum IgG in growing foals
Autore:
Demmers, S; Johannisson, A; Grondahl, G; Jensen-Waern, M;
Indirizzi:
Swedish Univ Agr Sci, Fac Vet Med, Dept Large Anim Clin Sci, Unit ComparatPhysiol & Med, Uppsala, Sweden Swedish Univ Agr Sci Uppsala Sweden paratPhysiol & Med, Uppsala, Sweden Swedish Univ Agr Sci, Fac Vet Med, Dept Anat & Histol, S-75007 Uppsala, Sweden Swedish Univ Agr Sci Uppsala Sweden S-75007 tol, S-75007 Uppsala, Sweden
Titolo Testata:
EQUINE VETERINARY JOURNAL
fascicolo: 7, volume: 33, anno: 2001,
pagine: 676 - 680
SICI:
0425-1644(200111)33:7<676:NFASII>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMORPHONUCLEAR LEUKOCYTES; CHEMI-LUMINESCENCE; PERIPHERAL-BLOOD; RHODOCOCCUS-EQUI; IMMUNE-RESPONSE; HEALTHY FOALS; HORSES; IMMUNOGLOBULINS; COLOSTRUM; RECEPTORS;
Keywords:
horse; foals; neutrophil; phagocytosis; chemiluminescence; IgG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Demmers, S Swedish Univ Agr Sci, Fac Vet Med, Dept Large Anim Clin Sci, Unit ComparatPhysiol & Med, Uppsala, Sweden Swedish Univ Agr Sci Uppsala Sweden l & Med, Uppsala, Sweden
Citazione:
S. Demmers et al., "Neutrophil functions and serum IgG in growing foals", EQUINE V J, 33(7), 2001, pp. 676-680

Abstract

The aim of this study was to investigate the phagocytic and killing capacities as well as expression of CD18 of neutrophils obtained from healthy foals from birth to age 8 months. Blood was taken from 6 Standardbred foals at7 time-points between ages 2-56 days and thereafter once a month. For comparison, cells from 16 mature horses were evaluated. Neutrophil phagocytosisof yeast cells was assessed by flow cytometry after opsonisation with mature pooled serum, autologous serum or anti-yeast IgG. The killing capacity of the neutrophils, as indicated by the oxidative burst, was monitored by chemiluminescence. Serum IgG concentration was measured by radial immunodiffusion. In addition to clinical examination, the amount of serum amyloid A and the total leucocyte count were used as markers for infection. The phagocytic ability was impaired until age 3 weeks, when autologous serum was used as opsonin. Killing capacity was also low initially but, from 3 months onwards, chemiluminescence values were equal to or higher than in mature horses. Serum IgG decreased from 10 g/l at 2 days to 5 g/l at 2 months and then increased gradually to 10 g/l at the end of the study. These findings may inpart explain the increased susceptibility to bacterial infections in younghorses.

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Documento generato il 21/01/20 alle ore 06:58:58