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Titolo:
Opsonic capacity of foal serum for the two neonatal pathogens Escherichia coli and Actinobacillus equuli
Autore:
Grondahl, G; Sternberg, S; Jensen-Waern, M; Johannisson, A;
Indirizzi:
Swedish Univ Agr Sci, Fac Vet Med, Dept Large Anim Clin Sci, Uppsala, Sweden Swedish Univ Agr Sci Uppsala Sweden arge Anim Clin Sci, Uppsala, Sweden Swedish Univ Agr Sci, Fac Vet Med, Dept Anat & Histol, Uppsala, Sweden Swedish Univ Agr Sci Uppsala Sweden Dept Anat & Histol, Uppsala, Sweden Natl Vet Inst, Dept Dis Control & Biosecur, S-75007 Uppsala, Sweden Natl Vet Inst Uppsala Sweden S-75007 & Biosecur, S-75007 Uppsala, Sweden
Titolo Testata:
EQUINE VETERINARY JOURNAL
fascicolo: 7, volume: 33, anno: 2001,
pagine: 670 - 675
SICI:
0425-1644(200111)33:7<670:OCOFSF>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLOSTRUM-DEPRIVED FOALS; BACTERICIDAL CAPACITY; CORYNEBACTERIUM-EQUI; SEPTICEMIA; PHAGOCYTOSIS; HORSES; NEUTROPHILS; ANTIBODIES; LEUKOCYTES; CALVES;
Keywords:
horse; foals; phagocytosis; opsonisation; Escherichia coli; Actinobacillus equuli; IgGa; IgGb;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Grondahl, G Swedish Univ Agr Sci, Fac Vet Med, Dept Large Anim Clin Sci, Uppsala, Sweden Swedish Univ Agr Sci Uppsala Sweden in Sci, Uppsala, Sweden
Citazione:
G. Grondahl et al., "Opsonic capacity of foal serum for the two neonatal pathogens Escherichia coli and Actinobacillus equuli", EQUINE V J, 33(7), 2001, pp. 670-675

Abstract

Two of the most commonly isolated foal pathogens are Escherichia coli and Actinobacillus equuli. The hypothesis tested in this study was that young foals carry a lower opsonic capacity for these bacteria compared to adult horses. A flow-cytometric method for the phagocytosis of these by equine neutrophils was established. The opsonic capacity of serum from healthy foals from birth to age 6 weeks was evaluated and related to the concentrations ofIgGa and IgGb. Phagocytosis of yeast was used as a control. Serum was required for phagocytosis, with higher concentrations for E. coli than for A. equuli. Ingestion of colostrum led to a significantly higher serum opsonic capacity. After that, there was no consistent age-related trend for opsonic capacity for the different microbes. Foal serum showed similar or higher opsonisation of E. coli and A. equuli compared to serum from mature individuals. During the studied period, the predominance among IgG subisotypes switched from IgGb to IgGa. Although the overall correlation between concentrations of IgG subisotypes and serum opsonic capacity was poor, sera with IgGb levels below 1.9 mg/ml induced lower opsonisation of E. coli and yeast, butnot of A. equuli. Complement activation was important for opsonisation of all tested microbes. The results of this study are significant to the understanding of a key immunological facet in the pathophysiology of equine neonatal septicaemia in clinical practice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:23:55