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Titolo:
Exercise alters the immune response to equine influenza virus and increases susceptibility to infection
Autore:
Folsom, RW; Littlefield-Chabaud, MA; French, DD; Pourciau, SS; Mistric, L; Horohov, DW;
Indirizzi:
Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, Baton Rouge, LA 70803 USA Louisiana State Univ Baton Rouge LA USA 70803 , Baton Rouge, LA 70803 USA Louisiana State Univ, Sch Vet Med, Dept Comparat Biomed Sci, Baton Rouge, LA 70803 USA Louisiana State Univ Baton Rouge LA USA 70803 , Baton Rouge, LA 70803 USA Louisiana State Univ, Louisiana Agr Expt Stn, Dept Vet Sci, Baton Rouge, LA 70803 USA Louisiana State Univ Baton Rouge LA USA 70803 , Baton Rouge, LA 70803 USA
Titolo Testata:
EQUINE VETERINARY JOURNAL
fascicolo: 7, volume: 33, anno: 2001,
pagine: 664 - 669
SICI:
0425-1644(200111)33:7<664:EATIRT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
VOLUNTARY EXERCISE; HORSES; STRESS; EXPRESSION; ANTIBODY; SYSTEM;
Keywords:
horse; exercise; immunity; cytokine; equine influenza virus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Horohov, DW Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, Baton Rouge, LA 70803 USA Louisiana State Univ Baton Rouge LA USA 70803 e, LA 70803 USA
Citazione:
R.W. Folsom et al., "Exercise alters the immune response to equine influenza virus and increases susceptibility to infection", EQUINE V J, 33(7), 2001, pp. 664-669

Abstract

Equine influenza virus remains a major health concern for the equine industry in spite of ongoing vaccination programmes. Previous work has shown that the immune system of horses can be affected by strenuous exercise. The possible adverse consequence of exercise-induced alterations in lymphocyte responses measured in vitro was unknown. Here we demonstrate that subjecting vaccinated ponies to a 5 day strenuous exercise programme results in a significant suppression of their T cell-mediated immune response to equine influenza virus as measured by decreased lymphoproliferation and gamma interferon production measured in vitro. These same ponies also demonstrated increased susceptibility to influenza disease following a challenge exposure to the same strain of virus. Rested ponies that bad received the same vaccine and challenge were completely protected from disease. Our results demonstrate that exercise-induced suppression of the equine immune response to influenza virus can be associated with an increased susceptibility to disease.

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Documento generato il 25/01/20 alle ore 15:43:06