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Titolo:
The mucosal humoral immune response of the horse to infective challenge and vaccination with Equine herpesvirus-1 antigens
Autore:
Breathnach, CC; Yeargan, MR; Sheoran, AS; Allen, GP;
Indirizzi:
Univ Kentucky, Dept Vet Sci, MH Gluck Equine Res Ctr, Lexington, KY 40546 USA Univ Kentucky Lexington KY USA 40546 ine Res Ctr, Lexington, KY 40546 USA
Titolo Testata:
EQUINE VETERINARY JOURNAL
fascicolo: 7, volume: 33, anno: 2001,
pagine: 651 - 657
SICI:
0425-1644(200111)33:7<651:TMHIRO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIBODY ISOTYPE RESPONSES; SIMPLEX VIRUS-INFECTION; RESPIRATORY-TRACT; MONOCLONAL-ANTIBODIES; PASSIVE-IMMUNIZATION; HOMOLOGOUS STRAIN; PONIES; EHV-1; MICE; TRANSMISSION;
Keywords:
horse; equine herpesvirus-1; mucosal; antibody; isotype;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Breathnach, CC Univ Kentucky, Dept Vet Sci, MH Gluck Equine Res Ctr, Lexington, KY 40546 USA Univ Kentucky Lexington KY USA 40546 xington, KY 40546 USA
Citazione:
C.C. Breathnach et al., "The mucosal humoral immune response of the horse to infective challenge and vaccination with Equine herpesvirus-1 antigens", EQUINE V J, 33(7), 2001, pp. 651-657

Abstract

Equine herpesvirus-1 (ERV-1) remains a frequent cause of upper respiratorytract infection and abortion in horses worldwide. However, little is knownabout the local antibody response elicited in the upper airways of horses following exposure to EHV-1. This study analysed the mucosal humoral immuneresponse of weanling foals following experimental infection with virulent EHV-1, or vaccination with either of 2 commercial vaccines. Twenty weanlings were assigned to 5 groups and were inoculated with, or vaccinated against, EHV-1 following different regimens. Finally, all weanlings were simultaneously challenged intranasally with virulent EHV-I Army 183 (A183). Nasal wash and serum samples were collected at regular intervals until 13 weeks after final challenge. Nasal washes were assayed for EHV-1-specific equine IgGa, IgGb, IgG(T), IgA, IgM and total virus-specific antibody using an indirect, quantitative ELISA. Total serum antibody responses were also monitored,and clinical signs of EHV-disease were recorded for each individual. Virus-specific IgA dominated the mucosal antibody response elicited in weanlings inoculated with A183, being detectable at up to 3.1 mug/mg total IgA13 weeks after challenge. Neither inactivated EHV-1 administered i.m., norattenuated ERV-1 administered intranasally induced detectable mucosal antibodies. ERV-1-specific mucosal antibodies impeded ERV-1 plaque formation invitro. Such virus-neutralising antibody probably contributes to a reduction of shedding of ERV-1 from the respiratory tract of virus-infected horses.

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Documento generato il 02/06/20 alle ore 05:13:06