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Titolo:
Efficacy of a cold-adapted, intranasal, equine influenza vaccine: challenge trials
Autore:
Townsend, HGG; Penner, SJ; Watts, TC; Cook, A; Bogdan, J; Haines, DM; Griffin, S; Chambers, T; Holland, RE; Whitaker-Dowling, P; Youngner, JS; Sebring, RW;
Indirizzi:
Univ Saskatchewan, Dept Large Anim Clin Sci, Saskatoon, SK S7N 5B4, CanadaUniv Saskatchewan Saskatoon SK Canada S7N 5B4 skatoon, SK S7N 5B4, Canada Univ Saskatchewan, Dept Vet Microbiol, Saskatoon, SK S7N 5B4, Canada Univ Saskatchewan Saskatoon SK Canada S7N 5B4 skatoon, SK S7N 5B4, Canada Heska Corp, Ft Collins, CO 80525 USA Heska Corp Ft Collins CO USA 80525Heska Corp, Ft Collins, CO 80525 USA Univ Kentucky, Dept Vet Sci, Gluck Equine Res Ctr 108, Lexington, KY 40546USA Univ Kentucky Lexington KY USA 40546 Res Ctr 108, Lexington, KY 40546USA Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Biochem, Pittsburgh, PA 15261 USA
Titolo Testata:
EQUINE VETERINARY JOURNAL
fascicolo: 7, volume: 33, anno: 2001,
pagine: 637 - 643
SICI:
0425-1644(200111)33:7<637:EOACIE>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CONTROLLED TRIAL; DOMINANT-NEGATIVE MUTANTS; LIVE-VIRUS-VACCINE; ANTIBODY-RESPONSES; 3 EPIDEMICS; INFECTION; DISEASE; HORSES; PROTECTION; TRIVALENT;
Keywords:
horse; influenza; cold-adapted; vaccine; challenge trial;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Townsend, HGG Univ Saskatchewan, Dept Large Anim Clin Sci, Saskatoon, SK S7N 5B4, Canada Univ Saskatchewan Saskatoon SK Canada S7N 5B4 N 5B4, Canada
Citazione:
H.G.G. Townsend et al., "Efficacy of a cold-adapted, intranasal, equine influenza vaccine: challenge trials", EQUINE V J, 33(7), 2001, pp. 637-643

Abstract

A randomised, controlled, double-blind, influenza virus, aerosol challengeof horses was undertaken to determine the efficacy of a cold-adapted, temperature sensitive, modified-live virus, intranasal, equine influenza vaccine. Ninety 1-month-old influenza-naive foals were assigned randomly to 3 groups (20 vaccinates and 10 controls per group) and challenged 5 weeks, 6 and12 months after a single vaccination. Challenges were performed on Day 0 in a plastic-lined chamber. Between Days I and 10, animals were examined daily for evidence of clinical signs of influenza. Nasal swabs for virus isolation were obtained on Day 1 and Days 1 to 8 and blood samples for serology were collected on Days 1, 7 and 14. There was no adverse response to vaccination in any animal. Following challenge at 5 weeks and 6 months, vaccinates had significantly lower clinical scores (P = 0.0001 and 0.005, respectively), experienced smaller increases in rectal temperature (P = 0.0008 and 0.0007, respectively) and shed less virus (P <0.0001 and P = 0.03, respectively) over fewer days (P <0.0001 and P = 0.002, respectively) than did the controls. After the 12 month challenge, rectal temperatures (P = 0.006) as well as the duration (P = 0.03) and concentration of virus shed (P = 0.04) were significantly reduced among vaccinated animals. The results of this study showed that 6 months after a single dose of vaccine the duration and severity of clinical signs were markedly reduced amongst vaccinated animals exposed to a severe live-virus challenge. Appropriate use of this vaccine should lead to a marked reduction in the frequency, severity and duration of outbreaks of equine influenza in North America.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:21:49