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Titolo:
Distinct cellular localization and regulation of endothelin-1 and endothelin-converting enzyme-1 expression in the bovine corpus luteum: Implicationsfor luteolysis
Autore:
Levy, N; Gordin, M; Mamluk, R; Yanagisawa, M; Smith, MF; Hampton, JH; Meidan, R;
Indirizzi:
Hebrew Univ Jerusalem, Dept Anim Sci, Fac Agr Food & Environm Qual Sci, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem Rehovot Israel IL-76100 , IL-76100 Rehovot, Israel Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 ward Hughes Med Inst, Dallas, TX 75235 USA Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 Ctr, Dept Mol Genet, Dallas, TX 75235 USA Univ Missouri, Dept Anim Sci, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 Dept Anim Sci, Columbia, MO 65211 USA
Titolo Testata:
ENDOCRINOLOGY
fascicolo: 12, volume: 142, anno: 2001,
pagine: 5254 - 5260
SICI:
0013-7227(200112)142:12<5254:DCLARO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIG ENDOTHELIN-1; GENE-EXPRESSION; CELLS; PROSTAGLANDIN-F2-ALPHA; RECEPTOR; METALLOPROTEASE; VASOCONSTRICTOR; IDENTIFICATION; ANGIOGENESIS; PROGESTERONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Meidan, R Hebrew Univ Jerusalem, Dept Anim Sci, Fac Agr Food & Environm Qual Sci, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem Rehovot Israel IL-76100 Rehovot, Israel
Citazione:
N. Levy et al., "Distinct cellular localization and regulation of endothelin-1 and endothelin-converting enzyme-1 expression in the bovine corpus luteum: Implicationsfor luteolysis", ENDOCRINOL, 142(12), 2001, pp. 5254-5260

Abstract

Endothelin-1 (ET)-1 within the corpus luteum (CL) is rapidly up-regulated during natural or PGF(2 alpha)-induced luteolysis; however, such an increase was not observed at early luteal stage when the CL is refractory to PGF(2alpha). The mature and active form of ET-1 is derived from the inactive intermediate peptide, big ET-1, by ET-converting enzyme (ECE)-1. This study therefore examined the developmental and cell-specific expression of ECE-1 in bovine CL. A significant, 4-fold, elevation in ECE-1 expression (mRNA andprotein levels) occurred during the transition of the CL from early to midluteal phase. Analysis using in-situ hybridization and enriched luteal cellsubpopulations showed that both steroidogenic and endothelial cells of theCL expressed high levels of ECE-1 mRNA, prepro ET-1 mRNA, on the other hand, was only expressed by resident endothelial cells. These data suggest that luteal parenchymal and endothelial cells may cooperate in the biosynthesis of mature bioactive ET-1. In the mature CL, ECE-1 mRNA increase occurred both in steroidogenic and endothelial cells and was accompanied by a significant rise in ET-1 peptide. However, in contrast to ECE-1, prepro ET-1 mRNAlevels were similar in early and midluteal-phase CL. Low ECE-1 levels during the early luteal phase, restricting the production of active ET-1, may explain why the immature CL is able to withstand PGF(2 alpha)-induced luteolysis.

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Documento generato il 19/09/20 alle ore 21:44:35