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Titolo:
Evaluating the risks of engineered viruses: Modeling pathogen competition
Autore:
Dushoff, J; Dwyer, G;
Indirizzi:
Acad Sinica, Inst Phys, Taipei 11529, Taiwan Acad Sinica Taipei Taiwan 11529 Sinica, Inst Phys, Taipei 11529, Taiwan Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46628 USA Univ Notre Dame Notre Dame IN USA 46628 iol Sci, Notre Dame, IN 46628 USA
Titolo Testata:
ECOLOGICAL APPLICATIONS
fascicolo: 6, volume: 11, anno: 2001,
pagine: 1602 - 1609
SICI:
1051-0761(200112)11:6<1602:ETROEV>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR-POLYHEDROSIS-VIRUS; IMPROVED BACULOVIRUS INSECTICIDE; TRICHOPLUSIA-NI LEPIDOPTERA; UDP-GLUCOSYL TRANSFERASE; GYPSY-MOTH LEPIDOPTERA; WILD-TYPE; RECOMBINANT BACULOVIRUSES; AUTOGRAPHA-CALIFORNICA; POPULATION-DYNAMICS; HELIOTHIS-VIRESCENS;
Keywords:
baculovirus; biological control; coexistence of virus strains; competition models; competitive exclusion; ecdysteroid UDP-glucosyl transferase (egt(-)); genetic engineering; gypsy moth; insect-baculoviras interaction; nuclear polyhedrosis virus (NPV); recombinant viruses;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Dushoff, J Princeton Univ, Dept Ecol & Evolut Biol, Princeton, NJ 08544 USA Princeton Univ Princeton NJ USA 08544 Princeton, NJ 08544 USA
Citazione:
J. Dushoff e G. Dwyer, "Evaluating the risks of engineered viruses: Modeling pathogen competition", ECOL APPL, 11(6), 2001, pp. 1602-1609

Abstract

Recently there has been a great deal of interest in the potential use of genetically engineered baculoviruses as environmentally benign insecticides. Because baculoviruses often have a significant impact on the population dynamics of their hosts, any effort to assess the environmental impact of releasing engineered viruses must confront the question: Will genetically engineered baculoviruses outcompete wild-type strains, thereby altering the natural population dynamics of the host? To begin to answer this question, we develop a mathematical model of competitive interactions between genetically engineered and wild-type baculoviruses. We find that the interactions between these viruses are characterized mostly by dominance of one strain or the other, and that the chance that an engineered strain will outcompete a wild-type strain depends on its particular combination of speed of kill and infectiousness. That is, baculoviruses must kill their host to become infectious, so the faster speed of kill of most recombinant viruses confers a competitive advantage. Most such strains, however, also produce fewer infectious particles and so are less infectious. Our model shows that the extent of this decrease in infectiousness must be rather small for an engineered strain to become dominant. Nevertheless, even engineered strains that are at a substantial competitive disadvantage relative to the wild type may take decades to go extinct. An additional complicating factor is that the outcomeof competition depends on the overwinter survival of these viruses, about which little is known even for wild-type viruses. Caution is therefore necessary in predicting the outcome of competitive interactions involving introduced baculoviruses, and further work is needed in understanding pathogen overwinter survival rates.

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Documento generato il 25/09/20 alle ore 12:34:11