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Titolo:
Fetal tissue transplantation for patients with Parkinson's disease - A database of published clinical results
Autore:
Clarkson, ED;
Indirizzi:
USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA USA Aberdeen Proving Ground MD USA 21010 een Proving Ground, MD 21010 USA
Titolo Testata:
DRUGS & AGING
fascicolo: 10, volume: 18, anno: 2001,
pagine: 773 - 785
SICI:
1170-229X(2001)18:10<773:FTTFPW>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; RIGHT CAUDATE-NUCLEUS; LONG-TERM SURVIVAL; DOPAMINE NEURONS; MESENCEPHALIC TISSUE; SUBSTANTIA-NIGRA; GRAFT-SURVIVAL; INTRASTRIATAL TRANSPLANTATION; NEURAL TRANSPLANTATION; VENTRAL MESENCEPHALON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Clarkson, ED USA, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA USA 3100 Ricketts Point Rd Aberdeen Proving Ground MD USA 21010
Citazione:
E.D. Clarkson, "Fetal tissue transplantation for patients with Parkinson's disease - A database of published clinical results", DRUG AGING, 18(10), 2001, pp. 773-785

Abstract

Over the past 13 years approximately 300 patients with Parkinson's diseasehave received transplants of human fetal dopamine cells in an attempt to reduce or control disease symptoms. Many of these patients have had improvements in their motor skills and a reduction in their daily levodopa administration. However, improvements are far from guaranteed and questions need tobe answered before this technique can be widely applied. To help address some of these issues, a search of all the published results of patients withParkinson's disease transplanted with human fetal tissue was conducted. This generated a database of 70 transplant recipients who had their levodopa administration and clinical benefit reported both prior to transplant and at least 6 months post- transplant. Furthermore, the number of years of disease onset prior to transplant was available for all recipients. This database was examined for motor improvement and reduction in levodopa dosage for up to 2 years post-transplant to determine the effects of time on transplant outcome. The database showed that most recipients had significant improvements in motor skills and levodopa administration, and that most benefits were observed in the first 6 months post-transplant. In addition, the database demonstrated that the number of years of disease onset prior to transplantation was not a predictor of patient outcome 1-year post-transplant. Current and future directions in fetal tissue transplantation research and replacements for fetal tissue are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:02:13