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Titolo:
Management of painful diabetic neuropathy
Autore:
Jensen, PG; Larson, JR;
Indirizzi:
Univ Iowa Hosp & Clin, Dept Pharmaceut Care, Iowa City, IA 52242 USA Univ Iowa Hosp & Clin Iowa City IA USA 52242 are, Iowa City, IA 52242 USA
Titolo Testata:
DRUGS & AGING
fascicolo: 10, volume: 18, anno: 2001,
pagine: 737 - 749
SICI:
1170-229X(2001)18:10<737:MOPDN>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CONTROLLED TRIAL; PLACEBO-CONTROLLED TRIAL; ALPHA-LIPOIC ACID; PERIPHERAL NEUROPATHY; DOUBLE-BLIND; SYMPTOMATIC TREATMENT; IMIPRAMINE TREATMENT; TRANSDERMAL CLONIDINE; CURRENT PERCEPTION; TOPICAL CAPSAICIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
85
Recensione:
Indirizzi per estratti:
Indirizzo: Jensen, PG Urbandale Family Phys, 2901 86th St, Urbandale, IA 50322 USA Urbandale Family Phys 2901 86th St Urbandale IA USA 50322 2 USA
Citazione:
P.G. Jensen e J.R. Larson, "Management of painful diabetic neuropathy", DRUG AGING, 18(10), 2001, pp. 737-749

Abstract

Type 2 diabetes mellitus is a prevalent disease in the US which affects more than 15 million people. As the disease progresses over time. neuropathicpain can become a common complication; it is present in more than 50% of individuals with diabetes mellitus aged > 60 years. The pathogenesis of diabetic neuropathy is theorised to be multifactorial. Numerous medications, some with different mechanisms of action, have been examined regarding their effects on the symptoms associated with diabetic neuropathy such as pain, paraesthesia and numbness. However, the majority of the studies have included small patient populations. Tricyclic antidepressants, amitriptyline and desipramine in particular, have been relatively well studied and shown to beeffective. However, anticholinergic adverse effects may limit their usefulness and may preclude use in the elderly. Studies have also shown gabapentin to be effective and well tolerated in the treatment of diabetic neuropathy. Capsaicin cream provides another treatment option with a favourable adverse effect profile. Many other medications have been evaluated in diabetic neuropathy; however, more placebo-controlled studies with adequate patient populations need to be performed to solidify their role in treatment.

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Documento generato il 01/12/20 alle ore 22:58:59