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Titolo:
Looking into anti-angiogenic gene therapies for disorders of the eye
Autore:
Rasmussen, HS; Rasmussen, CS; Durham, RG; King, CR; Wei, L;
Indirizzi:
GenVec, Gaithersburg, MD 20878 USA GenVec Gaithersburg MD USA 20878GenVec, Gaithersburg, MD 20878 USA
Titolo Testata:
DRUG DISCOVERY TODAY
fascicolo: 22, volume: 6, anno: 2001,
pagine: 1171 - 1175
SICI:
1359-6446(20011115)6:22<1171:LIAGTF>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPITHELIUM-DERIVED FACTOR; ENDOTHELIAL GROWTH-FACTOR; CEREBELLAR GRANULE CELLS; MACULAR DEGENERATION; DIABETIC-RETINOPATHY; RETINA; VECTOR; NEOVASCULARIZATION; EXPRESSION; INHIBITOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Rasmussen, HS GenVec, 65 W Watkins Mill Rd, Gaithersburg, MD 20878 USA GenVec 65 W Watkins Mill Rd Gaithersburg MD USA 20878 78 USA
Citazione:
H.S. Rasmussen et al., "Looking into anti-angiogenic gene therapies for disorders of the eye", DRUG DISC T, 6(22), 2001, pp. 1171-1175

Abstract

Age-related macular degeneration (AMD) and proliferative diabetic retinopathy (DR) are the most common causes of visual impairment in the developed world. Because the key factor in AMD and DR is aberrant neovascularization in the retina (DR) or in the choroid (AMD), strategies to inhibit abnormal neovascularization represent a compelling therapeutic approach. Here we review various anti-angiogenic strategies for the treatment of ocular neovascular diseases with special emphasis on gene transfer as a way of achieving high, sustained concentrations of antiangiogenic proteins in the back of the eye without concomitant systemic toxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:04:01