Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of adhesives and permeation enhancers on the skin permeation of captopril
Autore:
Park, ES; Chang, SJ; Rhee, YS; Chi, SC;
Indirizzi:
Sung Kyun Kwan Univ, Coll Pharm, Suwon 440746, South Korea Sung Kyun Kwan Univ Suwon South Korea 440746 , Suwon 440746, South Korea
Titolo Testata:
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
fascicolo: 9, volume: 27, anno: 2001,
pagine: 975 - 980
SICI:
0363-9045(2001)27:9<975:EOAAPE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCISED RABBIT SKIN; VITRO PERCUTANEOUS-ABSORPTION; HEALTHY-SUBJECTS; BIOAVAILABILITY; PENETRATION; DISEASES; DELIVERY; FOOD;
Keywords:
adhesive; enhancer; captopril; transdermal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Chi, SC Sung Kyun Kwan Univ, Coll Pharm, Suwon 440746, South Korea Sung Kyun Kwan Univ Suwon South Korea 440746 440746, South Korea
Citazione:
E.S. Park et al., "Effects of adhesives and permeation enhancers on the skin permeation of captopril", DRUG DEV IN, 27(9), 2001, pp. 975-980

Abstract

To formulate a transdermal drug delivery system of captopril, monolithic adhesive matrix type patches containing 20% captopril, different pressure-sensitive adhesives, and various permeation enhancers were prepared using a labcoater. The effects of the adhesives and permeation enhancers on skin permeation of captopril from the prepared patches were evaluated using Franz diffusion cells fitted with excised rat skins. The permeation rate of the drug through the excised skin was dependent on the type of polyacrylate copolymers studied. Fatty alcohols resulted in a pronounced enhancing effect on the skin permeation of captopril, while dimethyl sulfoxide, N-methyl-2-pyrrolidone, oleic acid, Transcutol, and polysorbate 20 showed no significant enhancing effect. The permeation-enhancing effect of the fatty alcohols reached the maximum at the level of 10%. Based on these results, a captopril patch may be developed with further optimization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:51:32