Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A nifedipine coground mixture with sodium deoxycholate. I. Colloidal particle formation and solid-state analysis
Autore:
Suzuki, H; Ogawa, M; Hironaka, K; Ito, K; Sunada, H;
Indirizzi:
Janssen Kyowa Co Ltd, Fuji Lab, Nagaizumi, Shizuoka 4110932, Japan JanssenKyowa Co Ltd Nagaizumi Shizuoka Japan 4110932 uoka 4110932, Japan Meijo Univ, Fac Pharm, Tempaku Ku, Nagoya, Aichi 4688503, Japan Meijo Univ Nagoya Aichi Japan 4688503 ku Ku, Nagoya, Aichi 4688503, Japan
Titolo Testata:
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
fascicolo: 9, volume: 27, anno: 2001,
pagine: 943 - 949
SICI:
0363-9045(2001)27:9<943:ANCMWS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CO-GROUND MIXTURE; DISSOLUTION BEHAVIOR; ORAL BIOAVAILABILITY; MICROCRYSTALLINE CELLULOSE; SIZE REDUCTION; D-MANNITOL; IMPROVEMENT; PHENYTOIN; DRUGS; ACID;
Keywords:
coground mixture; colloidal particle; intermolecular interaction; nifedipine; sodium deoxycholate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, H Janssen Kyowa Co Ltd, Fuji Lab, 600-8 Minamiisshiki, Nagaizumi, Shizuoka 4110932, Japan Janssen Kyowa Co Ltd 600-8 Minamiisshiki Nagaizumi Shizuoka Japan 4110932
Citazione:
H. Suzuki et al., "A nifedipine coground mixture with sodium deoxycholate. I. Colloidal particle formation and solid-state analysis", DRUG DEV IN, 27(9), 2001, pp. 943-949

Abstract

Sodium deoxycholate (DCNa) is a bile salt that forms multimolecular inclusion compounds with a variety of organic substances. In this study, complex formulation of DCNa with nifedipine, a poorly water soluble drug, by grinding was investigated. The coground mixture was prepared with a vibration rodmill, and its solid state was characterized using powder X-ray diffraction, differential scanning calorimetry (DSC), and Fourier transform infrared (FTIR) spectroscopy. A laser diffraction particle size analyzer was also used to determine the particle size distribution curve in solution. When a nifedipine-DCNa (1:2 w/w) mixture coground for 30 min was dispersed into waterand a pH 6.8 buffer solution, a semitransparent colloidal solution occurred immediately; 90% of the total particles formed in solution had a diameterless than 600 nm. Both powder X-ray diffraction peaks and DSC endothermic peak of nifedipine crystals were not found for the coground mixture, whereas a new exothermic peak was observed on DSC thermograms. The magnitude of this exothermic peak depended on the weight fraction of DCNa and the grinding time, indicating that nifedipine crystals changed into an amorphous stateby complex formation with DCNa during the grinding process. In the FTIR spectrum of the coground mixture, the peaks of aromatic CH out-of-plane bend and dihydropyridine NH stretch of nifedipine were considerably weakened, suggesting that van der Waals interaction may be present between the drug andDCNa molecules. From these results, it is clear that the cogrinding methodwith DCNa is very useful for the formation of amorphous nifedipine in the solid state and the production of colloidal particles of the drug in solution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:46:44