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Titolo:
Cardiac patterning and morphogenesis in zebrafish
Autore:
Yelon, D;
Indirizzi:
NYU, Sch Med, Skirball Inst Biomol Med, Dev Genet Program,Dept Cell Biol, New York, NY 10016 USA NYU New York NY USA 10016 Program,Dept Cell Biol, New York, NY 10016 USA
Titolo Testata:
DEVELOPMENTAL DYNAMICS
fascicolo: 4, volume: 222, anno: 2001,
pagine: 552 - 563
SICI:
1058-8388(200112)222:4<552:CPAMIZ>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART TUBE FORMATION; BHLH TRANSCRIPTION FACTOR; RIGHT AXIS FORMATION; ONE-EYED PINHEAD; CARDIOVASCULAR DEVELOPMENT; ANTEROPOSTERIOR POLARITY; VENTRAL MORPHOGENESIS; VERTEBRATE HEART; GENE-EXPRESSION; TINMAN HOMOLOGS;
Keywords:
heart; myocardium; ventricle; atrium; cardiac fusion; endoderm; valve; nkx2.5; gata5; fgf8; hand2; miles apart; heart and soul; jekyll;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
92
Recensione:
Indirizzi per estratti:
Indirizzo: Yelon, D NYU, Sch Med, Skirball Inst Biomol Med, Dev Genet Program,Dept Cell Biol, New York, NY 10016 USA NYU New York NY USA 10016 Dept Cell Biol, New York, NY 10016 USA
Citazione:
D. Yelon, "Cardiac patterning and morphogenesis in zebrafish", DEV DYNAM, 222(4), 2001, pp. 552-563

Abstract

Development of the embryonic vertebrate heart requires the precise coordination of pattern formation and cell movement. Taking advantage of the availability of zebrafish mutations that disrupt cardiogenesis, several groups have identified key regulators of specific aspects of cardiac patterning andmorphogenesis. Several genes, including gata5, fgf8, bmp2b, one-eyed pinhead, and hand2, have been shown to be relevant to the patterning events thatregulate myocardial differentiation. Studies of mutants with morphogeneticdefects have indicated at least six genes that are essential for cardiac fusion and heart tube assembly, including casanova, bonnie and clyde, gata5,one-eyed pinhead, hand2, miles apart, and heart and soul. Furthermore, analysis of the jekyll gene has indicated its important role during the morphogenesis of the atrioventricular valve. Altogether, these data provide a substantial foundation for future investigations of cardiac patterning, cardiac morphogenesis, and the relationship between these processes. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:12:20